中国南海圆盘肉芝软珊瑚的化学成分研究  

Studies on chemical constituents of Sarcophyton trocheliophrum

作　　者：何伶俐[1] 刘海利[2] 梁林富[2] 张洪斌[1] 郭跃伟[2] 

机构地区：[1]合肥工业大学制药工程系,安徽合肥230009 [2]中国科学院上海药物研究所新药研究国家重点实验室,上海201203

出　　处：《中国海洋药物》2013年第2期37-40,共4页Chinese Journal of Marine Drugs

基　　金：国家海洋"863"计划(2011AA09070102;2013AA092902);国家自然科学基金(81273430;21072204;21021063;40976048);中国科学院国家新药研究重点实验室项目(SIMM1203ZZ-03;SIMM1105KF-04);欧盟第七框架计划-IRS-ES项目(2010-2014)资助

摘　　要：目的研究圆盘肉芝软珊瑚的化学成分。方法利用柱层析方法分离纯化化合物并运用光谱学方法解析化合物结构。结果从中分离得到5个已知的西松烷型二萜,分别鉴定为7R*,8R*-epoxy-isoneocembrane A-16-oic methyl ester(1)、4-epithunbergol(2)、(-)-sarcophytoxide(3)、ent-sarcophine(4)、2-hydroperoxysar-cophine(5)。结论化合物1,2和5为首次从Sarcophyton属软珊瑚中分离得到。化合物2对人肺腺癌细胞株A-549和人白血病细胞株HL-60具有弱的细胞毒活性,化合物4具有弱的乙酰胆碱酯酶抑制活性。Objective To investigate the chemical constituents of the soft coral Sarcophyton trochelio- phrum. Methods The chemical constituents were isolated and purified using column chromatography. Their structures were determined through the analysis of spectroscopic data. Results Five known cem- brahe diterpenes were identified as 7R＊ , 8R＊-epoxy-isoneocembrane A- 16-oic methyl ester （1）, 4-epi- thunbergol （2）, （-）-sarcophytoxide （3）, ent-sarcophine （4）, and 2-hydroperoxysarcophine （5）, re- spectively. Conclusion Compounds 1, 2, and 5 were obtained from this genus for the first time. Com- pound 2 exhibited weak cytotoxicity against A-549 human lung carcinoma and HL-60 human promyelo- cytic leukemia cell lines, while compound 4 showed weak inhibitory activity against acetylcholinester- ase.

关 键 词：圆盘肉芝软珊瑚 化学成分 西松烷二萜 

分 类 号：R931.6[医药卫生—生药学]