脑心通胶囊中4个成分肠吸收研究  

Study on absorption location of four components from Naoxintong capsule

作　　者：黄斌[1,2] 李耿[3] 郭宇飞[1,2] 王松松[1] 刘峰 许海玉[1] 杨洪军[1] 

机构地区：[1]中国中医科学院中药研究所,北京100700 [2]江西中医学院,江西南昌330004 [3]中日友好医院,北京100029 [4]陕西陕西步长制药有限公司,陕西西安710075

出　　处：《中国中药杂志》2013年第6期889-893,共5页China Journal of Chinese Materia Medica

基　　金：国家"重大新药创制"科技重大专项(2011ZX09201-201-26)

摘　　要：目的:研究脑心通胶囊在小肠中的吸收特性。方法:应用外翻肠囊法制备肠吸收液,UPLC检测不同肠段中化学成分含量,比较脑心通胶囊中化学成分在各肠段的吸收情况;绘制时间-累积吸收曲线,观察累积吸收浓度随时间的变化情况。结果:阿魏酸、丹酚酸B、芍药苷在回肠和空肠后段的累积吸收浓度高于空肠前段和中段;阿魏酸、芍药苷、丹酚酸B、羟基红花黄色素A在3 h内吸收均未达到饱和状态。结论:阿魏酸、芍药苷、丹酚酸B、羟基红花黄色素A为全肠段吸收,阿魏酸、芍药苷、丹酚酸B可能存在部位特异性吸收。Objective： To study the absorption characteristics of four components from Naoxintong capsule in intestines. Meth od： In vitro everted gut sac method was adopted for preparing the intestinal absorption solution of Naoxintong capsule. UPLC was used to detect the content of chemical components in different intestinal segments, and comparing the results with the absorption of chemical components of Naoxintong capsule in each intestinal segment. The timeaccumulative absorption curve was drawn to observe the changes in the accumulative absorption concentration with time. Result： Four ingredients of Naoxintong capsule can be detected in intestinal absorption solution, they are ferulic acid, paeonif/orin, salvianolic acid B and hydroxysafflor yellow A. Specifically, the accumulative absorption concentrations of ferulic acid, salvianolic acid B and paeoniflorin in ileum and rear jejunum segments were higher than that in front and middle jejunum segments ; the absorption of ferulic acid, paeoniflorin, salvianolic acid B and hydroxysafflor yellow A did not reach saturated conditions in 3 hours. Conclusion： Ferulic acid, paeoniflorin, salvianolic acid B and hydroxysafflor yellow A are absorbed in the whole intestine. Ferulic acid, paeoniflorin and salvianolic acid B may be absorbed in specific segments.

关 键 词：脑心通胶囊 外翻肠囊 UPLC 吸收 

分 类 号：R285[医药卫生—中药学]