辛伐他汀对糖尿病患者尿液肾功能指标的影响  

Effects of Simvastatin on Urinary Renal Function in Patients with Diabetes Mellitus

作　　者：陆少锋[1] 李秀华[1] 陈荧[1] 

机构地区：[1]佛山市高明区人民医院,广东佛山528500

出　　处：《中国药房》2013年第12期1096-1097,共2页China Pharmacy

摘　　要：目的:考察辛伐他汀对糖尿病患者尿液肾功能指标的影响。方法:将我院78例尿常规检查尿蛋白为阴性的糖尿病患者随机分为试验组(40例)和对照组(38例),两组患者均给予常规降糖药物治疗,试验组同时给予辛伐他汀20mg口服,每晚1次。两组疗程均为6个月。比较两组患者治疗前及治疗6个月后免疫球蛋白G(IgG)、α1微球蛋白(α1-MG)、β2微球蛋白(β2-MG)、微量白蛋白(MA)、转铁蛋白(TRF)等尿液肾功能指标的变化,并观察不良反应情况。结果:治疗前,两组患者尿液肾功能各指标比较差异无统计学意义(P>0.05);治疗6个月后,对照组患者尿液肾功能各指标与治疗前比较差异无统计学意义(P>0.05),而试验组患者尿液肾功能各指标显著下降,与治疗前及对照组比较差异均有统计学意义(P<0.05)。两组患者均未见明显不良反应发生。结论:辛伐他汀治疗能减轻糖尿病患者的微量尿蛋白,改善尿液肾功能指标。OBJECTIVE： To investigate the effects of simvastatin on urinary renal function for patients with diabetes mellitus. METHODS： 78 patients with diabetes mellitus that urine protein was negative by urine routine examination were randomly divided into experimental group （40 cases） and control group （38 cases）. All patients in 2 groups were given routine hypogiycemic drugs. At the same time, the patients in experimental group were given oral simvastatin 20 mg once every night. Treatment course of 2 groups lasted for 6 months. Urinary renal function, including Immunoglobulin G （IgG）, a1 microglobulin （a1-MG）, f12 microglobulin （β2-MG）, microalbumin （MA） and transferrin （TRF）, were tested in all patients before and 6 months after treatment. The occurrence of ADR was observed in 2 groups. RESULTS： Before treatment, there was no statistical significance in urinary renal function between 2 groups （P〉0.05）. Before and 6 months after treatment, the index of urinary renal function had no statistical signifi- cance in control group （P〉0.05）. The index of urinary renal function in experimental group significantly were lower than control group and before treatment, there was statistical significance （P〈0.05）. No significant ADR was found in 2 groups. CONCLU- SION： Simvastatin can reduce microalbuminuria excretion and improve urinary renal function of patients with diabetes mellitus.

关 键 词：辛伐他汀 糖尿病 尿液肾功能指标 

分 类 号：R587.1[医药卫生—内分泌]