质子泵抑制剂与药物的相互作用  

INTERACTION BETWEEN PROTON PUMP INHIBITOR AND DRUG

作　　者：徐小平[1] 王曙[1] 陈聪[1] 贺英菊[1] 

机构地区：[1]华西医科大学药学院,四川成都610041

出　　处：《华西药学杂志》2000年第5期371-372,共2页West China Journal of Pharmaceutical Sciences

摘　　要：质子泵抑制剂奥美拉唑、兰索拉唑和盘托拉唑主要经细胞色素P45 0 (CYP)的异构酶CYP2C19代谢消除。研究表明 ,三个质子泵抑制剂对其它经CYP系列代谢的药物皆表现出较弱的相互作用 ,少数文献报道这一相互作用无临床相关性 ,并且未发现剂量与不良反应的相关性。Proton pump inhibitors were metabolized with the sub enzyme CYP2C19 of microsomes P450.The study shows that three of PPI were weak interaction with other drugs when CYP enzyme effected.Some of the research reported that there was not relative in clinic,also there was no relative with dose and side effect.Result infered that PPI is the safe drug both using and combining in clinic.

关 键 词：原子泵抑制剂 药物相互作用 肝药酶 CYP 

分 类 号：R969.2[医药卫生—药理学]