基线高敏C-反应蛋白水平与心源性猝死的相关性研究  

Study of relationship between the high sensitivity C-reactive protein level in baseline and sudden cardiac death events

作　　者：王剑利[1] 吴寿岭[1] 李云[2] 马宇杰[1] 李善庭[1] 王丽晔[1] 赵洪涛[1] 邢爱君[1] 李冬青[1] 王艳秀[1] 

机构地区：[1]华北煤炭医学院附属开滦医院,河北唐山063000 [2]华北煤炭医学院

出　　处：《现代预防医学》2013年第6期1017-1020,1023,共5页Modern Preventive Medicine

摘　　要：目的探讨血清高敏C-反应蛋白(hs-CRP)水平与心源性猝死(SCD)事件风险的相关性。方法采用回顾性巢式病例对照研究方法 ,选择SCD患者80例,对照组160例。比较两组间基线hs-CRP水平,分析不同基线hs-CRP水平与SCD事件的相关性。结果 SCD患者基线hs-CRP水平(1.26mg/L)高于对照组(0.59mg/L)(P﹤0.001);hs-CRP四分位数水平较高者(﹥2.01mg/L)发生SCD事件的风险是较低者(﹤0.31mg/L)的8.18倍(95%CI2.75～24.40,P﹤0.001),对hs-CRP以3mg/L及以第80百分位点为临界值分组后进行统计分析,hs-CRP与SCD事件相关性依然存在,OR值分别为4.26(95%CI1.98～9.15,P﹤0.001),3.86(95%CI1.71～8.72,P﹤0.001)。结论基线hs-CRP水平与SCD事件风险有相关性,hs-CRP水平较高者发生SCD的风险增加,hs-CRP≥3mg/L者SCD事件发生风险明显增加。OBJECTIVE To explore the relationship between hs-CRP level in baseline and the risk of sudden cardiac death （SCD） events. METHODS In a retrospective, nested, case-control study, 80 cases of SCD were identified and matched to 160 controls. The hs-CRP levels in baseline were compared between these two groups. Relevance of different hs-CRP levels and the risk of SCD events were analyzed. RESULTS The baseline levels of hs-CRP in SCD cases （1.26rag/L） were higher than that in control group （0.595rag/L）, and the difference was significant （P 〈 0.001 ）. In addition, the increase in risk associated with hs-CRP levels was primarily observed that the individuals with the highest quartile hs-CRP levels （ 〉 2.01mg/L） had an increased risk of SCD （OR： 8.18, 95%CI 2.75-24.40） compared with those in the lowest quartile （ 〈 0.31rag/L）. Individuals with baseline hs-CRP levels above the pre-specified cut point of 3 mg/L or above the 80th percentile were at a markedly in- creased risk of SCD （for pre-specified cut point of 3 rag/L, OR = 4.26, 95%CI 1.98-9.15, P 〈 0.001 ; for 80th percentile, OR = 3.86, 95%CI 1.71-8.72, P 〈 0.001, respectively）. CONCLUSION Risk of SCD events might be related with the level of hs-CRP. With the increase of hs-CRP level in baseline, the risk of SCD was increased.

关 键 词：高敏C-反应蛋白 心源性猝死 危险因素 巢式病例对照研究 

分 类 号：R540.4[医药卫生—心血管疾病]