广西抗结核药品不良反应研究分析  

Research on adverse drug reactions of anti-tuberculosis in Guangxi

作　　者：黄敏莹[1] 罗丹[1] 刘飞鹰[1] 李鹃[1] 

机构地区：[1]广西壮族自治区疾病预防控制中心,广西南宁530028

出　　处：《现代预防医学》2013年第6期1146-1148,1151,共4页Modern Preventive Medicine

摘　　要：目的了解广西抗结核板式组合药不良反应的发生情况,评价其对结核病治疗效果的影响。方法采用前瞻性研究方法 ,对随机抽取的14个县(区)2007年10月～2008年6月期间所有使用免费抗结核板式药品治疗的涂阳肺结核患者,进行基线、随访和结局调查。结果上述调查人群抗结核药物不良反应发生率为12.36%,其中肝损害发生率最高(3.7%),其次为胃肠道(3.5%)和过敏反应(3.4%)。随着年龄增大,不良反应发生率增高。不良反应多发生在抗结核治疗强化期,有61.2%的药品不良反应导致患者中断和终止治疗、减少用药量、更换药物和改变服药方式。23.7%的药品不良反应导致患者的病程延长、病情恶化和死亡。结论广西抗结核药品不良反应发生率与国内平均水平相似,其中以肝损害最为常见,是导致治疗中断和病程延长的主要原因。建立和健全药品不良反应监测系统有助于该区不良反应的预防与控制。OBJECTIVE To find the situation of adverse drug reactions （ADRs） of anti-tuberculosis and evaluate its impact on tuberculosis treatment. METHODS Baseline surveys, follow-up and outcome surveys were taken on the smear-positive cases selected by simple random sampling in 14 counties during October, 2007 to January, 2008. RESULTS The incidence of ADRs was 12.36%, the rate of Antituberculosis drug-induced hepatotoxicity （ATDH） was the highest in all types of ADRs （3.7%）, followed by gastrointestinal ADRs （3.5%） and allergic ADRs （3.4%）. The rate of ADR increase was in accord with age. Most ADRs occurred at the fist 2 months of TB treatment. 61.2% ADRs took impact on TB treatment, including treatment interrup- tion, termination, replacement of drugs, lower dose or changing the administration of drugs, 23.7% ADRs impacted on tuber- culosis prognosis, such as illness worsen, death.etc. CONCLUSION The incidence of ADRs in Guangxi was at the national av- erage level. ATDH was the most common type of ADRs, and also the main type of ADRs leaded to treatment interruption. Moni- toring system must be strengthened to prevent and control ADRs.

关 键 词：涂阳肺结核 抗结核药品 不良反应 

分 类 号：R521[医药卫生—内科学]