基于分子信标的自组装模型研究展望  

Research Expectation of Self-Assembled Model Based on Mlolecular Beacon

作　　者：殷志祥[1] 张文逸[1] 

机构地区：[1]安徽理工大学理学院,安徽淮南232001

出　　处：《信息工程期刊（中英文版）》2013年第1期13-18,共6页Scientific Journal of Information Engineering

基　　金：本文得到国家自然科学基金（60873144,61170172,61073102,60973050）7）.安徽理工大学本科生研究项目资助.

摘　　要：自组装DNA计算和分子信标DNA计算模型是近年来DNA计算研究领域的热点，自组装DNA计算是DNA计算、tiling理论和纳米技术结合的产物，分子信标具有结构简单、灵敏度高、易于检测及反应速度快等优点。将分子信标与自组装相结合，将为DNA计算研究提供新的有效方法。介绍了基于分子信标的自组装模型研究的意义，自组装DNA计算模型和分子信标计算模型研究现状，以及基于分子信标的自组装模型研究的途径。首先研究分子信标的结构特性及分子信标的表达信息和处理信息的能力，深入研究自组装DNA计算机理及优化设计的组装规则，讨论分子信标的自组装方法及复杂性分析，构建分子信标的自组装模型；其次建立组合优化问题的基于分子信标自组装模型，进一步讨论分子信标自组装模型的优缺点并对设计方法进行改进，设计具有通用性的分子信标自组装模型。DNA computing using Self-Assembly and its model based on molecular beacon has been the focus in the research of DNA Computing in the recent years. Self-Assembled DNA computing is the result of the combination of DNA Computing, the theory oftiling and nanotechnology, and moreover, molecular beacon has the advantages of simple structure, high sensitivity, easily- measured and fast reaction rate. The combination of molecular beacon and Self-Assembly will provide a new effective method ofstudying DNA Computing. Introduce the significance of research about Self-Assembled model based on molecular beacon, researchful actuality of Self-Assembled DNA computing model and DNA computing model based on molecular beacon, as well asresearchful track of Self-Assembled model based on molecular beacon. The first of all, research about the characteristics of structure about molecular beacon and its capacity of the information expressed and handled, the deep research on the assemblyrules about the theory of Self-Assembled DNA computing and optimal design, discuss the Self-Assembled methods of molecular beacon and its complexity analysis in detail, create its model. Secondly, establish the Self-Assembled model based on molecularbeacon, which contains many combinatorial optimization problems. Furthermore, we make a further discussion on the advantages and the disadvantages about Self-Assembled model based on molecular beacon in order to design a new model with universality.

关 键 词：自组装 分子信标 DNA计算 矩阵加法 组合优化 

分 类 号：O224[理学—运筹学与控制论]