下呼吸道感染病原菌分布及耐药性分析  

The distribution and antibiotic resistance of pathogens isolated from nosocomial lower respiratory tract infection

作　　者：纪冰[1] 马筱玲[2] 付明霞[3] 宿振国[1] 彭新国[1] 王爱玲[1] 

机构地区：[1]滨州医学院附属医院检验科,山东滨州256603 [2]安徽省立医院检验科,安徽合肥230001 [3]山东省滨州市人民医院病理科,256600

出　　处：《蚌埠医学院学报》2013年第2期203-205,共3页Journal of Bengbu Medical College

基　　金：山东省高等学校科技计划资助项目(J09LF67);山东省自然科学基金资助项目(ZR2009CL002);滨州医学院校级科技计划资助项目(BY2007KJ27)

摘　　要：目的:了解住院患者下呼吸道感染病原菌分布及耐药特点,为临床合理用药提供依据。方法:采用K-B纸片法对3 024例住院患者下呼吸道感染的痰标本所分离的病原菌作药物敏感试验,采用WHO NET 5.4统计软件对数据进行分析。结果:分离的3 024株病原菌中,前5位依次为铜绿假单胞菌、肺炎克雷伯菌、鲍曼不动杆菌、金黄色葡萄球菌和大肠埃希菌。铜绿假单胞菌整体耐药率较低,鲍曼不动杆菌呈多重耐药;除亚胺培南和美罗培南外,肠杆菌科细菌对其他抗菌药物的耐药率总体上呈逐年上升趋势;金黄色葡萄球菌中耐甲氧西林金黄色葡萄球菌的分离率较高,表现为多重耐药。结论:下呼吸道感染病原菌以G-杆菌为主,主要的病原菌对临床常用抗菌药物耐药严重。Objective：To investigate the distribution and antibiotic resistance of pathogens isolated from nosocomial lower respiratory tract infection for rational antimicrobial therapy. Methods： Kirby-Bauer method was used to test the drug susceptibihty of clinical isolated pathogenic bacteria from 3 024 patients＇ sputum. The data were analyzed by WHO NET 5.4 software. Results： In 3 024 clinical isolated pathogenic bacteria,the top five pathogens were P. aeruginosa, K. p neumoniae,A, baumanii, S. aureus and E. coli. The overall drug resistance rate of P. aeruginosa was low,A, baumanii was multi-drug resistant pathogen, the resistance rate of enterobacteriace to antibiotics was increased in recent years except imipenem and meropenem, the rate of methicillin resistant S. aureus was high in S. aureus,and was shown multiple resistance to antibiotics. Conclusions： Gram-negative bacilli are the major pathogens in nosocomial lower respiratory tract infection, antibiotic resistance becomes more prevalent in some major pathogens.

关 键 词：呼吸道感染 病原菌 耐药性 

分 类 号：R517.6[医药卫生—内科学]