健康成人血清邻苯三酚法测定超氧化物歧化酶参考范围的建立  

Establishment of the reference range of serum superoxide dismutase measured by pyrogallol autoxidation method in healthy adults

作　　者：武强[1] 

机构地区：[1]复旦大学附属上海市第五人民医院检验科,上海200240

出　　处：《检验医学》2013年第2期114-116,共3页Laboratory Medicine

摘　　要：目的建立健康成人血清邻苯三酚法超氧化物歧化酶(SOD)参考范围。方法采用邻苯三酚法测定1 640名健康成年人血清中SOD浓度,并按年龄、性别进行分组统计。结果健康成人血清SOD水平呈正态分布,与年龄呈负相关(r=-0.541,P<0.01)。男、女组间差异有统计学意义(P<0.01)。SOD参考范围:男性≤40岁为147.6～218.4 U/mL,41～60岁为131.4～207.8 U/mL,>60岁为98.1～190.9 U/mL;女性≤40岁为142.0～205.2 U/mL,41～60岁为126.4～194.4 U/mL,>60岁为95.5～187.5 U/mL。结论 SOD参考范围在不同人群中是不一致的,实验室应根据各自的检测系统和检测方法制定合理的参考范围。Abstract：Objective To establish the reference value of superoxide dismutase（SOD） measured by pyrogallol autoxidation method in healthy adults. Methods 1640 clinical serum samples for SOD were detected by pyrogallol autoxidation method in healthy adults,and the results were statisticed according to sex and age. Results The distribution of serum SOD was normal in health adults,and the levels were negatively correlated with ages（r=-0.541,P〈0.01）.There was a significant difference in the levels of SOD between males and females（P〈0.01）.The reference range in males： 147.6～218.4 U/mL in ≤40-year-old group,131.4～207.8 U/mL in 40 to 60-year-old group, 98.1～190.9 U/mL in 〉60-year-old group.And in females： 142.0～205.2 U/mL in ≤40-year-old group,126.4～194.4U/mL in 40 to 60-year-old group, 95.5～187.5 U/mL in 〉60-year-old group. Conclusions The reference range of serum SOD are inconsistent in different healthy people,it is essential to establish the rational reference value by respective detection system and detection method in different clinical laboratory.

关 键 词：超氧化物歧化酶 邻苯三酚 参考范围 

分 类 号：Q554[生物学—生物化学]