砷对实验小白鼠某些生化指标的影响  

Effects of Arsenic on Some Biochemical Indices in Experimental Mice

作　　者：潘秀琴[1] 王连方[2] 刘惠君[2] 田欣[3] 张玲[2] 林勤[2] 

机构地区：[1]新疆医科大学第一附属医院,新疆乌鲁木齐830054 [2]新疆地方病防治研究所,新疆乌鲁木齐830002 [3]新疆维吾尔自治区人民医院,新疆乌鲁木齐830001

出　　处：《地方病通报》2000年第3期10-12,共3页Endemic Diseases Bulletin

基　　金：国家自然科学基金! (39660 0 71 ) ;卫生部科学研究基金!(96- 1 - 373)

摘　　要：对砷暴露实验动物血清进行常用生化指标观察 ,结果显示 2 4项指标中除 6项指标实验组与对照组接近外 ,18项指标有不同程度改变 ,其中 BUN、Na、AL B、L DH、AL P、Cr、BUN/ Cr、BG等项两组间有显著差异 ,提示砷对动物生化指标有一定影响 ,为研究人类砷中毒生化指标变化提供线索。Some common biochemical indices of mice serum from arsenic experiment were observed with an automatic biochemical analyzer. A total of 18 out of 24 indices observed had some changes between experimental group and control group. Compared with the control group, six indices (BUN, Na, ALB, LDH, ALP and BUN/Cr) increased obviously in the group of arsenic experiment. On the other hand, blood glucose and creatinine in experimental group were lower than that in control group. Some indices had better changes in the groups of protective cure with sulfydryl group preparation. The findings suggested that some biochemical indices could be interfered in arsenic intake, and rendered some clues of biochemistry change for human arsenic poisoning.

关 键 词：砷 生物化学 动物实验 白鼠 NIH 

分 类 号：R995[医药卫生—毒理学] Q5－33[医药卫生—药学]