早期应用颈动脉给药治疗脑梗死临床研究  

Treatment of Cerebral Infarction by Administration of Drugs Through Cervical Artery in Early Stage

作　　者：杨光[1] 吴松林[1] 赵扬[1] 赵霞[1] 

机构地区：[1]南京中医药大学第三附属医院,江苏南京210001

出　　处：《南京中医药大学学报》2000年第5期274-276,共3页Journal of Nanjing University of Traditional Chinese Medicine

基　　金：江苏省科委自然科学基金! (BK99139)

摘　　要：:目的　探讨早期应用颈动脉给药治疗发病 1周内的动脉粥样硬化性血栓性脑梗死 (以下简称脑梗死 )的临床疗效。方法颈动脉给药 5 8例 ;常规静脉给药 5 2例 ,疗程、药物及总剂量相同 ,1个月后观察肢体功能恢复程度、时间、头颅CT、经颅多普勒超声 (TCD)、血液流变学、血小板、出血 (BT)及凝血 (CT)时间。结果　动脉组总有效率 91.38% ,静脉组总有效率 76 .92 % (P <0 .0 5 ) ,动脉组肢体功能恢复程度、痊愈患者所需时间、患侧脑血流量的变化与静脉组相比差异显著 ,而血液流变学、血小板及出凝血时间变化 2组无差异 (P >0 .0 5 )。结论　颈动脉给药治疗脑梗死急性期效果好于静脉给药 ,其机理与改变了给药途径有关。OBJECTIVE To determine the therapeutic effect of the treatment of cerebral infarction by giving drugs through the cervical artery in the early stage of the diseases.METHODS Drug administration through cervical artery was given to 58 patients and routine drug administration through the vein was given to 52 patients. The duration of treatment course, kinds of drugs and dosage of the drugs were the same in the two groups. After one month of treatment, the results were observed in the following areas: body function restoration, cranium CAT scanning results, Doppler ultrasonic examination, blood rheology, blood platelet, and time of bleeding and coagulation.RESULTS The effective rates in the artery group and vein group was 91.38% and 76.92% respectively ( P <0.05). In the artery group, the degree of body function restoration, the time for recovery and changes in the brain blood flow were significantly different from those in the vein group, whereas there were no marked differences in blood rheology, blood platelet and time of bleeding and coagulation ( P >0.05).CONCLUSION Drug administration through the artery is better than through the vein, the mechanism of which lies in the fact that the changed route of drug administration may change the coagulating mechanism of the body.

关 键 词：给药途径 脑梗死 中医药疗法 颈动脉给药 

分 类 号：R255.205[医药卫生—中医内科学]