药物累积法探讨天麻钩藤饮等3方的体内毒效动力学  

A Study of In Vivo Toxic Dynamics of Tianmagouteng Decoction etc.Three Prescriptions with Pharmaceutical Cumulative Method

作　　者：赵智强[1] 陆跃鸣[1] 俞晶华 李嘉 周仲瑛 

机构地区：[1]南京中医药大学中医药研究院,江苏南京210029

出　　处：《南京中医药大学学报》2000年第5期284-286,共3页Journal of Nanjing University of Traditional Chinese Medicine

基　　金：江苏省科委自然科学基金! (BK97112 ) ;江苏省教委自然科学基金! (JW970 0 80 )

摘　　要：目的　估测天麻钩藤饮、镇肝熄风汤、建瓴汤 3个平肝熄风代表方的毒效动力学参数。方法　将药物动力学中多点动态测定的原理与动物死亡率测定药物蓄积性的方法结合起来 ,即用多组动物 ,按不同的间隔时间给药 ,求出不同时相下的体存百分率以观察方药中毒性成分在体内的动态变化 ,进而求出相关药代动力学参数。结果　 3方均属二房室模型分布 ,基本上按一级动力学消除。天麻钩藤饮、镇肝熄风汤、建瓴汤的半数致死量分别为 5 8.0 4g/kg、10 0 .2 2g/kg、98.74g/kg ;表观消除速率常数为 0 .0 18、0 .0 11、0 .0 2 1;表观消除半衰期为 39.13h、6 1.49h与 32 .40h ;表观分布速率常数分别为 0 .0 92、0 .0 6 9、0 .144 ;表观分布半衰期为 7.5 2h、10 .0 8h与 4.80h ,3方毒性作用对性别影响无明显差异。结论　 3方似具有明显的毒性作用 ,这可能与毒效法测定时的腹腔给药途径有关。OBJECTIVE To estimate the toxic dynamics parameter of three representative prescriptions for calming the liver wind, i.e. Tianmagouteng Decoction, Zhengganxifeng Decoction, and Jianling Decoction.METHODS Several groups of animals were given the drugs with different intervals of time to work out the pharmacokinetics parameter.RESULTS The half lethal doses of Tianmagouteng Decoction, Zhengganxifeng Decoction, and Jianling Decoction were 58.04 g/kg, 100.22 g/kg and 98.74 g/kg respectively. The apparent removal rates were 0.018, 0.011 and 0.021. The apparent removal half life periods were 39.13 h, 61.49 h and 32.40 h. The apparent distribution rate constants were 0.092, 0.069 and 0.144. The apparent distribution half life periods were 7.52 h, 10.08 h and 4.08 h. There was no marked sex difference in the toxic effect of the three decoctions. This paper also presents discussions on the estimation method for pharmacokinetics parameter using toxic effect method.CONCLUSION The three prescriptions seem to have marked toxic side effect;which may have to do with the drug administraton throug the abdomen in the toxic determination.

关 键 词：天麻钩藤饮 镇肝熄风汤 药物累积法 毒效动力学 

分 类 号：R285.5[医药卫生—中药学]