血栓通注射液联合贝那普利对糖尿病肾病临床疗效的观察  

Clinical efficacy of Xueshuantong injection combined with benazepril for diabetic nephropathy

作　　者：薛松妍[1] 蒋宏伟[2] 张晓菊[1] 姚锐[1] 袁平[1] 任得志 李锋[1] 

机构地区：[1]第四军医大学西京医院中医科,西安710032 [2]陕西省人民医院中西医结合研究所 [3]陕西省中医医院心病科

出　　处：《山西医科大学学报》2013年第3期227-230,共4页Journal of Shanxi Medical University

基　　金：陕西省科技厅基金资助项目(2009k17-04)

摘　　要：目的观察血栓通注射液联合贝那普利对糖尿病肾病(DN)临床疗效的改善,探讨其作用机制。方法选择40例辨证为血瘀证的Ⅲ期DN患者,按照随机数字表将患者分为对照组(贝那普利组)和治疗组(贝那普利加血栓通注射液),每组20例,于试验2周末检测尿白蛋白、尿白蛋白排泄率(UAER)、血清肌酐(Scr)、尿素氮(BUN),观察患者水肿、腰部冷痛及酸软等临床症状的改善。结果与对照组相比,治疗组对DN患者的蛋白尿有一定的减少作用,差异有统计学意义(P<0.05),两组治疗后血清肌酐(Scr)、尿素氮(BUN)差异无统计学意义(P>0.05)。治疗后患者的水肿、腰部冷痛及酸软、疲倦懒动、肌肤甲错、口黏口干等临床症状都得到有效的改善。结论血栓通联合贝那普利对DN患者有明显的保护作用,其机制可能与血栓通改善其血瘀状态有关。Objective To observe the clinical efficacy of Xueshuantong injection combined with benazepril for diabetic nephropathy（DN）,and to explore its therapeutic mechanism.Methods Forty cases of phase Ⅲ DN patients with blood stasis pattern were randomized into control group（benazepril group） and trial group（Xueshuantong injection combined with benazepril）.The level of urinary albumin,urinary albumin excretion rate（UAER）,blood urea nitrogen（BUN）,serum creatinine（Scr）were measured at the end of 2 weeks.The clinical efficacy was compared.Results Compared with control group,the incidence of albuminuria decreased significantly in trial group（P〈0.05）.There was no significant difference in Scr and BUN between two groups after treatment（P〈0.05）.After treatment,the clinical symptoms were effectively improved in both groups.Conclusion Xueshuantong injection combined with benazepril can significantly protect DN patients by improving the blood stasis state.

关 键 词：血栓通 贝那普利 糖尿病肾病 蛋白尿 

分 类 号：R692[医药卫生—泌尿科学]