血清salusin-α水平与男性勃起功能障碍的相关性研究  

Correlation between serum salusin-α levels and erectile dysfunction in male patients

作　　者：郭巍[1] 陈美霓[2] 白安胜[1] 

机构地区：[1]延安大学附属医院泌尿外科,延安716000 [2]延安大学医学院实验中心

出　　处：《山西医科大学学报》2013年第3期237-239,共3页Journal of Shanxi Medical University

基　　金：陕西省教育厅科学研究基金资助项目(12JK0713);延安大学自然科学专项基金资助项目(ydz2012-03)

摘　　要：目的探讨血清salusin-α水平与男性勃起功能障碍相关性。方法采用横断面研究,共纳入104名男性勃起功能障碍患者(ED组,n=104),并纳入年龄-体重指数匹配的健康对照者68名(对照组,n=68),使用酶联免疫吸附(ELISA)法检测各组的血清salusin-α水平。通过logistic回归分析评价各变量与男性勃起功能障碍的相关性。结果 ED组患者的血清salusin-α水平明显低于对照组[(1.19±0.36)vs(2.68±0.71)ng/ml,P<0.01]。logistic回归分析结果显示血清salusin-α水平与男性勃起功能障碍呈独立负相关(优势比0.886,95%CI 0.813-0.946,P<0.01)。结论低血清salusin-α水平是男性勃起功能障碍发生的独立危险因子,检测血清salusin-α水平有望成为预测男性勃起功能障碍风险的重要手段。Objective To investigate the correlation between serum salusin-α levels and erectile dysfunction（ED） in male patients.Methods A total of 104 male ED patients（ED group,n=104） and 68 age/body mass index（BMI）-matched healthy controls（control group,n=68） were cross-sectionally enrolled in this study.Serum salusin-α levels were measured by enzyme-linked immunosorbent assay（ELISA）.The correlation between variables and the presence of ED was investigated by logistic analysis.Results Serum salusin-α levels were significantly lower in ED patients than those in healthy controls [（1.19±0.36） vs（2.68±0.71） ng/ml,P〈0.01].Logistic regression revealed that serum salusin-α level was independently and negatively associated with the occurrence of ED in male patients（OR 0.886,95%CI 0.813-0.946,P〈0.01）.Conclusion Lower serum salusin-α level may be an independent risk factor for the occurrence of ED in male patients.The detection of serum salusin-α level might be a useful method for predicting the occur-rence of ED in male patients.

关 键 词：男性 性功能障碍 salusin-α 生物标记物 

分 类 号：R698[医药卫生—泌尿科学]