磷酸化多糖的研究进展  

Research progress of phosphorylated polysaccharides

作　　者：李全才[1] 李春霞[1] 勾东霞[1] 管华诗[1] 

机构地区：[1]中国海洋大学医药学院,海洋药物教育部重点实验室,山东省糖科学与糖工程重点实验室,青岛266003

出　　处：《生命科学》2013年第3期262-268,共7页Chinese Bulletin of Life Sciences

基　　金：海洋公益性行业科研专项基金(201005024);长江学者和创新团队发展计划(IRT0944);山东省科技发展计划(2011GSF11815);青岛市公共领域科技支撑计划项目(11-2-3-73-jh)

摘　　要：磷酸化多糖作为多糖的重要衍生物,具有免疫调节、抗肿瘤、抗病毒等多种生物活性,是研究多糖构效关系不可或缺的一部分。磷酸化多糖广泛存在于自然界中,结构复杂多样。鉴于天然磷酸化多糖分离困难繁琐,磷酸化多糖的化学合成引起了人们的重视,发展了诸多多糖磷酸化的方法。从天然磷酸化多糖、多糖磷酸化方法、磷酸化多糖的生物活性及应用三个方面简要介绍了磷酸化多糖的研究进展。Phosphorylated polysaccharides which are important derivatives of polysaccharides, have a variety of bioactivities, such as immunoregulation, antitumor, antivirus and so on. Phosphorylated polysaccharides are widely distributed in nature and have complex structures. Because the separation of natural phosphorylated polysaccharides is difficult and trival, chemical synthesis draws people＇s attention and many methods have been developed. In this paper, the progress of phosphorylated polysaccharides was elaborated from three aspects including natural phosphorylated polysaccharides, methods of phosphorylation of polysaccharides and bioactivities of phosphorylated polysaccharides.

关 键 词：多糖 天然磷酸化多糖 磷酸化 生物活性 

分 类 号：Q539[生物学—生物化学]