金威消石颗粒对小鼠的镇痛作用  

Analgesic Effect of Jinwei Lithiasis-eliminating Granules on Mice with Intraperitoneal Injection of Acetic Acid

作　　者：杨中良[1] 杨秀云[2] 曲晓璐[1] 胡庆禧 李剑[1] 刘卫东 

机构地区：[1]上海市浦东新区浦南医院中西医结合科重症监护室,200125 [2]浙江省立同德医院内科,杭州310012 [3]上海双基药业有限公司,201319 [4]上海市蓝十字医学科学研究所,200125

出　　处：《医药导报》2013年第2期166-167,共2页Herald of Medicine

基　　金：上海市卫生局中医药开发研究基金(2011XY011)

摘　　要：目的观察金威消石颗粒对腹腔注射醋酸小鼠的镇痛作用。方法健康雄性ICR小鼠60只,随机分为金威消石颗粒低、中、高剂量组,阳性对照组和阴性对照组,分别经胃灌注不同剂量金威消石颗粒、双氯芬酸钠溶液和纯化水,每日1次,连续7 d。于末次给药后1 h,各小鼠腹腔注射0.7%醋酸溶液0.2 mL,计数注射后20 min内小鼠扭体次数。结果金威消石颗粒不同剂量组小鼠腹腔注射醋酸后扭体次数明显少于阴性对照组(P<0.01);金威消石颗粒组与阳性对照组比较差异无统计学意义。结论金威消石颗粒对小鼠具有明显的镇痛作用。Objective To explore the analgesic effect of finwei lithiasis-eliminating granules on mice with intraperitoneal injection of acetic acid. Methods Sixty healthy male ICR mice were randomly divided into 5 groups ： treatment groups （low-, middle- and high-dose groups）, positive control group and negative control group, with each group having 12 mice. Jinwei lithiasis-eliminating granules （ 1.33, 2.66 and 5.32 g ·kg-1 ） , diclofenac sodium and isovolemic distilled water were administered by gavage in the mice of above-mentioned groups, respectively, once daily, for 7 days. Each mouse was injected intraperitoneally with 0.2 mL of 0.7% acetic acid 1 h just after the final perfusion, and the writhing times of all mice was counted within 20 rains after injection. Results The mean writhing times was significantly less in the treatment groups than in the negative control group （P〈0.01）. There was no significant difference between the treatment groups and the positive control group. Conclusion Jinwei lithiasis-eliminating granules are shown to have considerable analgesic effect.

关 键 词：金威消石颗粒 双氯芬酸钠 镇痛作用 扭体次数 

分 类 号：R286[医药卫生—中药学] R965[医药卫生—中医学]