氯氰碘柳胺钠的合成工艺研究  

Studying Synthesis of Closantel Sodium

作　　者：史磊 徐梅桔 

机构地区：[1]杭州科本药物研究有限公司研发部,浙江杭州311121 [2]杭州汉达医药科技有限公司分析部,浙江杭州310011

出　　处：《广东化工》2013年第5期14-15,共2页Guangdong Chemical Industry

摘　　要：目的:研究氯氰碘柳胺钠的合成工艺。方法以对氯苯乙腈、邻硝基对氯甲苯等为原料,经缩合、还原、缩合、成盐4步反应合成氯氰碘柳胺钠。结果:选择了合适的工艺条件以及确定了详细的反应操作过程,所得的氯氰碘柳胺钠质量(干燥失重,含量)符合中国兽药质量标准的要求,合成总收率达到约43%。结论:本方法可靠,可用于氯氰碘柳胺钠的合成。Object To study synthesis process of Closantel Sodium. Methods Closantel Sodium was synthesized from 4-chlorobenzeneacetonitrile and 1-chloro-4-methyl-3-nitrobenzene etc. via condensation, deoxidization, condensation, forming salt. Results To select a good synthesis process condition and formulate a detailed synthesis process, the total yield was about 43 %. The product＇s loss on drying and content conform with the request of Chinese veterinary drugs quality standards. Conclusions The method is reliable, and can be used for synthesis of Closantel Sodium.

关 键 词：氯氰碘柳胺钠 对氯苯乙腈 邻硝基对氯甲苯 合成工艺研究 

分 类 号：TQ[化学工程]