活性维生素D在老年慢性疾病防治中的地位  

Active VataminD in the Prevention and Treatment for Chronic Disease of the Elderly

作　　者：夏云阶 陈其章 马镇江[2] 

机构地区：[1]甘肃省老年医学研究所,中国兰州730000 [2]甘肃省宕昌县人民医院心内科,中国宕昌748500

出　　处：《国际老年医学杂志》2013年第2期76-83,共8页International Journal of Geriatrics

摘　　要：维生素D不仅对人体钙、磷代谢平衡重要，而且近些年研究发现VitD受体广泛存在于人体的多种组织细胞中，活性维生素D还具有重要生物学功能。VitD缺乏与多种慢性疾病发生相关，包括骨质疏松、骨折、跌倒风险增加；增加心血管风险，包括高血压、缺血性心脏病、心力衰竭；而且影响胰腺β细胞分泌及胰岛素抵抗，从而增加2型糖尿病风险。活性VitD调节人体固有免疫和获得性免疫，调控细胞生长，促进细胞分化，抑制细胞增殖及免疫平衡，从而影响免疫系统疾病和肿瘤发生、发展。应适量补充VitD对人体许多组织器官发挥最佳功能，有益于老年慢性疾病防治和健康。The most important function of vitamin D is to maintain the balance of human calcium and phoephorus metabolism. The newest research have found that vitamin D receptors （VDR） present in a variety of tissue cells. Active vitamin D also has essential biological functions： Vitamin D deficiency is many chronic diseases risk factor, including osteoprosis, catactasis with increasing risk of falling daw; vitD deficiency also increases the risk of cardiovascular diseases such as hypertension, atheroclerosis, ischamic heart disease and heart failure etc. And it influences the synthesis or secretion of insulin from βcell as well as insulin resistence. So it can increase the danger of type 2 diabetes. Active vitD can adjust both inherent immunity and obtained immunity. It regulates cell growth, improves cell differetiation, inhibits cell proliferation and help the ballance of immunity, which will cause illness of immune system and the oecurance and development of cancer. Suitable supplement of vitD can prevent from chromic diseases usefully.

关 键 词：活性维生素D 骨质疏松 心血管疾病 2型糖尿病 免疫系统 肿瘤 

分 类 号：R692.5[医药卫生—泌尿科学]