吡哌酸锌对实验性胃溃疡的保护作用  

Protective effects of zinc pipemidate on experimental gastric ulcers

作　　者：刘春霞[1] 尹志奎[1] 刘晓丽[1] 杨玉亭[1] 刘巨源[1] 张小毅[1] 

机构地区：[1]新乡医学院药理教研室,河南新乡453003

出　　处：《新乡医学院学报》2000年第4期240-241,244,共3页Journal of Xinxiang Medical University

摘　　要：目的　探讨吡哌酸锌对实验性胃溃疡的作用及作用机制。方法　健康大鼠和小鼠 ,均衡随机分为 5组 ,即阴性对照组 (羧甲基纤维素钠 )、阳性对照组 (西咪替丁 )、吡哌酸锌 2 5mg·kg-1、5 0mg·kg-1和10 0mg·kg-1剂量组 (小鼠剂量加倍 ) ,每组 10只 ,分别观察对 4种实验性胃溃疡的作用。结果　吡哌酸锌对各种胃溃疡模型的抑制率与阴性对照组相比差异显著 (P <0 .0 1) ,并呈剂量依赖性。结论　吡哌酸锌对实验性胃溃疡有保护作用。Objective To study the effects of zinc pipemidate on experimental gastric ulcers and its mechanism.Methods Normal rats and mice were randomly dirvided into 5 groups including negative control group(sodium carboxymethyl cellulose),positive control group(cimetidine),groups of zinc pipemidate(25mg·kg -1 ,50mg·kg -1 and 100mg·kg -1 ) in rat (50mg·kg -1 ,100mg·kg -1 and 200mg·kg -1 groups in mice).Each group included 10 animals. The effects of zinc pipemidate on experimental gastric ulcers were observed . Results Zine pipemidate produced dose-dependent relationship and significance hibitory effects on gastric ulcers, compared with the control group . Conclusion Zinc pipemidate pressesses protective effects on experimental gastric ulcer.

关 键 词：吡哌酸锌 实验性胃溃疡 西咪替丁 治疗 药理 

分 类 号：R975.6[医药卫生—药品] R573.105[医药卫生—药学]