愈肝汤对慢性乙型肝炎患者脂质过氧化和肝纤维化的影响  

Affection of Yugan decoction(愈肝汤) on lipid peroxydation and liver fibrosis in chronic hepatitis B

作　　者：王宪波[1] 乔汉臣[1] 桑雁[1] 乔立新[1] 

机构地区：[1]新乡医学院第一附属医院,河南卫辉453100

出　　处：《新乡医学院学报》2000年第4期242-244,共3页Journal of Xinxiang Medical University

摘　　要：目的　探讨慢性乙型肝炎 (CHB)患者脂质过氧化与肝纤维化的关系及愈肝汤的抗肝纤维化作用。方法　用放射免疫法测定 5 3例CHB患者血清透明质酸 (HA)、Ⅲ型前胶原 (PCⅢ )、Ⅳ型胶原 (ⅣC)和层粘蛋白 (LN)水平 ,用硫代巴比妥酸比色法测定过氧化脂质 (LPO) ,分析肝纤维化血清学指标与LPO关系 ;5 3例CHB患者随机分为治疗组和对照组 ,观察愈肝汤治疗后患者HA、PCⅢ、ⅣC、LN和LPO水平变化。结果　随着病情加重 ,患者HA、PCⅢ、ⅣC、LN和LPO水平增高 (P <0 .0 5或P <0 .0 1) ,而且HA、PCⅢ、ⅣC、LN均与LPO呈正相关 ;愈肝汤能够降低上述肝纤维化血清学指标和LPO水平 (P <0 .0 5或P<0 .0 1)。结论　脂质过氧化反应与肝纤维化发生发展有密切关系 ;愈肝汤有抗肝纤维化作用 ,这可能与其本身抗脂质过氧化作用有关。Objective To study the relationship between lipid peroxydation(LPO) and liver fibrosis and anti-hepatofibrosis of Yugan decoction in chronic Hepatitis B (CHB).Methods The serum levels of hyaluronic alid (HA),procollagenⅢ (PCⅢ) , type Ⅳ collagen (ⅣC) and laminin (LN) were determined by radioimmunoassay ,and the LPO levels were measured by turbidimetry in 53 CHB patients. Fifty threc CHB patients were divided into two groups, and the serum levels of HA, PCⅢ, ⅣC, LN and LPO in before and after treatment were compared. Results As the illness progresses, the serum levels of HA, PCⅢ,ⅣC,LN and LPO were increased (P<0.05 or P<0.01),and the levels of HA, PCⅢ, ⅣC and LN had a parallel relationship with the LPO levels. The Yugan decoction can decrease aforementioned parameters of hepatofibrosis and LPO (P<0.05 or P<0.01). Conclusion The action of LPO are correlation closely with development and progress of hepatofibrosis. The Yugan decoction has anti-hepatofibrosis effect and the effect may be correlated with it`s against action of lipid peroxydation .

关 键 词：乙型肝炎 HA PCⅢ 愈肝汤 中医药疗法 IVC LPO 

分 类 号：R259.126.2[医药卫生—中西医结合]