糖化血红蛋白和N末端脑钠肽原与急性冠脉综合征心功能的关系  

Association of HbAlc and NT-proBNP with cardiac function in patients with acute coronary syndrome

作　　者：陈志刚[1] 姚红波[1] 张永莉[1] 岳兵[1] 关慧灵[1] 

机构地区：[1]新乡医学院第一附属医院心脏病科,河南省453100

出　　处：《江苏医药》2013年第5期543-545,共3页Jiangsu Medical Journal

摘　　要：目的探讨糖化血红蛋白(HbA1c)和N-末端脑钠肽前体(NT-proBNP)的表达水平与急性冠脉综合征(ACS)患者心功能的关系。方法检测ACS患者68例(A1组,38例,合并糖尿病;A2组,30例,无糖尿病)和健康体检者20名(B组)血清HbA1c和NT-proBNP水平。结果 A1组血清HbA1c水平明显高于A2组和B组[(9.47±1.62)%vs.(5.86±0.31)%和(5.64±0.22)%](P<0.01),但A2组和B组之间无统计学差异(P>0.05)。A1、A2组血清NT-proBNP均明显高于B组[(441.84±78.63)μg/ml、(217.31±34.52)μg/ml vs.(86.33±15.26)μg/ml](P<0.01),且A1组NT-proBNP高于A2组(P<0.01)。在ACS患者,血清HbA1c和NT-proBNP水平随着心功能病情加重而明显增加(P<0.05或P<0.01)。ACS患者血清HbA1c和NT-proBNP水平呈显著正相关(r=0.524,P<0.05)。结论 ACS患者血清HbA1c和NT-proBNP水平明显升高;联合检测血清HbA1c和NT-proBNP可以用于ACS患者心功能的评估。Objective To investigate the relationship of glycosylated hemoglobin （HbAlc）, N-terminal pro-brain natriuretic peptide（NT-proBNP） and cardiac function in the patients with acute coronary syndrome（ACS）. Methods Serum levels of HbAlc and NT-proBNP were detected in 68 ACS patients with diabetes（group A1,38 cases） or without diabetes（group A2, 30 cases） and 20 healthy people（group B）. Results Serum levels of HbAlc were higher in group of A1 than those in groups of A2 and B[（9. 47±1.62）% vs. （5.86±0. 31）% and （5.64±0. 22）%] （P〈0. 01）,which were not significantly different between groups of A2 and B（P〉0. 05）. Serum levels of NT-proBNP were higher in groups of A1 and A2 than those in group B（P〈0. 01） ,which was higher in group A1 than those in group A2（P〈0. 01）. The level of serum HbAlc was positively correlated with that of NT-proBNP in ACS patients （r=0. 524, P〈0. 05）. Conclusion Serum levels of HbAlc and NT-proBNP in ACS patients are remarkably elevated. Combined detection of HbAlc and NT-proBNP can be used to evaluate the cardiac function in ACS natients.

关 键 词：急性冠脉综合征 糖化血红蛋白 N-末端脑钠肽前体 

分 类 号：R543[医药卫生—心血管疾病]