Th9细胞的研究进展  

Research Progress of Th9 Cell

作　　者：邓勇[1] 苏智军[1] 

机构地区：[1]福建医科大学附属泉州市第一医院感染科,福建泉州362000

出　　处：《医学综述》2013年第5期779-782,共4页Medical Recapitulate

基　　金：泉州市科技计划项目(2011Z63)

摘　　要：Th9细胞是近期发现的一类CD4+亚群效应性T细胞,由转化生长因子β(TGF-β)和白细胞介素(IL)4共同培养的条件下由静息T细胞诱导产生,也可以由TGF-β单独诱导Th2细胞分化而成,PU.1和干扰素调节因子4基因被认为是Th9细胞分化的特异的转录因子。小鼠实验表明Th9细胞可大量分泌细胞因子IL-9和IL-10。但与小鼠不同的是,人Th9细胞不分泌IL-10。Th9细胞在过敏性疾病、抗寄生虫感染和自身免疫性疾病中起着重要作用。Th9细胞亚群的发现,为这些疾病的病因学及临床诊断治疗的研究找到了新的突破口。Th9 is a subset of CD4 ＋ effector T cells recently discovered.It can be induced by resting T cell under the condition of TGF-β co-cultured with IL-4,and can aslo be induced by Th2 differentiation from TGF-β alone.PU.1 and IRF-4 gene is considered as the peculiar transcription factor of human Th9 cells.Murine experiments show that Th9 can secrete large quantities of IL-9 and IL-10.However,in contrast to murine Th9 cell,IL-10 is not expressed by human Th9 cell.Th9 plays an important role in allergic diseases,anti-parasitic infection and the adjustment of autoimmune disease.The discovery of Th9 subset has brought a breakthrough to the pathology and clinical diagnosis and treatment of these diseases.

关 键 词：TH9细胞 白细胞介素9 过敏性哮喘 寄生虫感染 自身免疫性疾病 

分 类 号：R512.6[医药卫生—内科学]