糖尿病肾病的早期诊断与氧化低密度脂蛋白、转铁蛋白的检测  

The Early Stage Diagnosis of Diabetic Nephpropathy with the Measurement of OX-LDL and TRF

作　　者：刘智勇[1] 彭苹[1] 何凤娥[1] 涂屹[1] 李春北[1] 

机构地区：[1]攀枝花市中心医院,四川攀枝花617067

出　　处：《四川省卫生管理干部学院学报》2000年第3期170-171,共2页Journal of Sichuan Continuing Education College of Medical Sciences

摘　　要：目的 :为探讨糖尿病肾病 (DN)的早期诊断方法。方法 :用酶联法对 139例 2型糖尿病患者和 40例对照进行OX LDL、TRF及UAER的测定。结果 :糖尿病患者OX LDL和TRF水平显著高于对照组 (P <0 .0 1) ,糖尿病伴肾病患者的水平显著高于无肾病患者 (P <0 .0 1) ;在各组中OX LDL及TRF与UAER有明显的相关性 (P <0 .0 1)。结论 :提示作为DN的早期诊断的指标 ,OX LDL、TRF与UAER具有相同意义 ,并且该两项指标可能较UAER更敏感。Objective:To study the early stage diagnostic methods for diabetic nephropathy.Methods:The level of OX-LDL、TRF and UAER was measured by ELISA in 139 cases with type-2 diabetes mellitus and 46 controls.Results:The level of OX-LDL and TRF in type-2 diabetic patients was significantly higher than that of controls( P<0.01) ;It was also significantly higher in type-2 diabetic patients with nepropathy than that of without nepropathy( P <0.01).A close interrelation exists between OX-LDL、TRF or UAER in each group( P <0.01).Conclusion:The same significance between OX-LDL、TRF and UAER can be looked as an index of the early stage diagnosis of the DN.The former two indices were more sensitive than that of UAER to the early stage diagnosis of the DN.

关 键 词：Ⅱ型糖尿病 糖尿病肾病 氧化低密度脂蛋白 诊断 

分 类 号：R587.204[医药卫生—内分泌]