静脉注射丙种球蛋白无反应型川崎病的研究进展  

Progress in research on the Kawasaki disease irresponsive to IVIG treatment

作　　者：李丰[1] 张园海[1] 仇慧仙[1] 任跃[1] 陈其[1] 

机构地区：[1]温州医学院附属育英儿童医院儿童心血管科,浙江温州325027

出　　处：《临床儿科杂志》2013年第3期283-286,共4页Journal of Clinical Pediatrics

摘　　要：川崎病（KD）是一种病因不明的以全身中、小血管炎为主要病变的儿童急性发热性疾病。如未经治疗,约20%~25%的KD患儿可发生冠状动脉损害（CAL）。尽管目前标准化疗法已广泛应用,但仍有10%~15%的患儿对静脉注射丙种球蛋白（IVIG）无反应,且这部分患儿发生CAL的风险升高。因此,早期识别及有效治疗KD十分重要,现就这方面的研究进展进行综述。Kawasaki disease（KD） is an acute febrile childhood vasculitis,associated with the development of coronary artery lesion（CAL） in 20%-25% of untreated patients.The aetiopathogenesis is not well known.Now standardized therapy has been widely used,but there are 10%-15% of the cases no response to intravenous immunoglobulin treatment（IVIG）,and these patents are at higher risk for CAL.Therefore,early recognition and effective treatment of such cases is very important,this article reviews the recent progress in this field.

关 键 词：川崎病 丙种球蛋白 无反应 

分 类 号：R725.4[医药卫生—儿科]