超声波对阿洛西林酸晶体形态的影响  

Effect of Ultrasound on Crystal Morphology of Azlocillin Acid

作　　者：张光雷[1] 王永莉[1] 张东亚[1] 

机构地区：[1]天津大学化工学院,天津300072

出　　处：《化学工业与工程》2013年第2期14-18,共5页Chemical Industry and Engineering

基　　金：国家自然科学基金资助项目(20836005)

摘　　要：针对阿洛西林酸(ALPC)生产中存在晶形差、产品聚结的问题,研究了超声波对ALPC晶体形态的影响。首先测定了纯水中的介稳区,分析了超声波影响产品晶习的机理,然后考察了超声波下初始浓度、流加速率和搅拌速率对阿洛西林酸反应结晶过程的影响,从而确定出了最适宜结晶工艺条件。结果表明:超声波可以改善阿洛西林酸产品的晶习、粒度分布并能降低产品聚结程度,实验所得符合厂家的要求。Considering the problem of non-uniform crystal morphology and agglomeration of Azlocillin acid （ALPC） in the production process, effects of ultrasound on the crystal morphology of Azlocillin acid were studied. Firstly, the metastable zone of water-ALPC system and the formation mechanism of crystal habit affected by ultrasound were analyzed, and the phenomena were explained through monitoring the change number of crystallization process by FBRM （Focused Beam Reflectance Measurement）. Then, in order to optimize the crystallization technology, factors such as initial concentration, dropping rate and agitation speed were investigated in ultrasound environment to determine their effects on the formation of ALPC, and the products were characterized by using optical microscopy, scanning electron and crystal particle size analyzer. Results show that the introduction of ultrasound can improve the crystal habit and size distribution of ALPC and decrease the agglomeration of ALPC under the optimum conditions, which are highly promising for the industrial production.

关 键 词：超声波 晶习 粒度分布 阿洛西林酸 

分 类 号：TQ465.1[化学工程—制药化工]