杞菊地黄丸对肝肾阴虚型先兆子痫预防作用研究  

Study of Preventive Effects of Qiju Dihuang Pill on Preeclampsia Belonging to Liver-Kidney Yin Deficiency

作　　者：李艳芳[1] 朱玲[1] 柯晓燕[1] 顾菁[2] 李道成[1] 

机构地区：[1]广州中医药大学第一附属医院,广东广州510405 [2]广州中山大学卫生统计学教研室,广东广州510080

出　　处：《辽宁中医药大学学报》2013年第4期38-41,共4页Journal of Liaoning University of Traditional Chinese Medicine

基　　金：广东省中医药管理局科研课题基金资助项目(2010168)

摘　　要：目的:探讨肝肾阴虚证与先兆子痫(PE)的相关性,评估杞菊地黄丸用于预防肝肾阴虚型PE的有效性和安全性。方法:通过对有PE高危因素的孕12～16周的孕妇进行中医辨证分型,凡辨证分型为肝肾阴虚型者,采用单盲随机对照的研究方法,随机分配到口服杞菊地黄丸的治疗组和空白对照组,并追踪、对比两组孕妇治疗后及孕晚期中医证型的转变、PE的发生率以及妊娠结局情况。结果 (:1)试验组孕妇口服杞菊地黄丸治疗2～4周后,47.7%转化为正常证型,在随访的相同时间段内,对照组有11.7%自动转化为正常证型;试验组在孕28周为正常证型者达54.7%,而对照组则有27.3%为正常证型。两组孕妇在治疗后及孕28周的中医证型分型均有显著性区别。(2)对照组孕妇分娩前的最高平均动脉压高于试验组,分娩孕周及新生儿出生体重则低于试验组,两组间的差别有统计学意义;对照组孕妇较试验组更倾向于发生PE及通过剖宫产术终止妊娠,但两组间的差别不存在统计学意义。结论:杞菊地黄丸在孕20周前使用能有效纠正肝肾阴虚型孕妇的证型,改善妊娠结局。Objective： To investigate the relation between liver-kidney yin deficiency and pre- eclampsia （ PE ）. To evaluate the efficacy and safety of Qiju Dihuang Pill used to prevent pre-eclampsia belonging to liver-kidney yin deficiency. Methods ： This was a sigle blind random controlled trail study. A total of 163 pregnant women at 12~16 gestational weeks with liver-kidney yin deficiency were randomly allocated into experimental group （ 86 cases ） and control group （ 77 cases ）. The women in experimental group were orally administrated by Qiju Dihuang Pill for 2-4 weeks but not in control group. The change of TCM syndrome after treatment and in late ~!tq^ester, the incidence rate of PE, and the pregnancy outcomes of the two groups were recorded and compared, l{esuhs ： （ 1 ） There was 47.7% of women after treatment and 54.7% of women at 28th week of gestation in experimental group changed into normal TCM syndrome, during the same follow-up period, the rates respectively were 11.7% and 27.3% in control group. The differences after treatment and at 28th week of gestation between two groups were statistically significant.（ 2 ） The women in control group had a higher mean arterial pressure before delivery, shorter gestational weeks at delivery and lower neonate birth weight as compared with those in the experimental group, the difference between two groups was statistically significant. The women in the control group were more likely to develop PE and deliver by cesarean section than those in the experimental group, but the differenc6s had no sense in statistics. Conclusion ： Qiju Dihuang Pill can be used to effectively treat liver-kidney yin deficiency before the 20th week of gestation and improve the pregnancy outcomes.

关 键 词：先兆子痫 阴虚证 杞菊地黄丸 妊娠 预防 

分 类 号：R714.244[医药卫生—妇产科学]