骨髓间充质干细胞在心血管疾病中的研究及应用  

Research and application of bone marrow mesenchymal stem cells in the treatment of cardiovascular diseases

作　　者：周岩[1] 朴金花[1] 金莲花[1] 杨思睿[1] 

机构地区：[1]吉林大学白求恩第一医院小儿心血管科,吉林省长春市130021

出　　处：《中国组织工程研究》2013年第1期112-117,共6页Chinese Journal of Tissue Engineering Research

基　　金：吉林省科技厅青年基金项目(201101069);吉林省发展和改革委员会项目(20100173)~~

摘　　要：背景:骨髓间充质干细胞具有多向分化潜能,对肝脏疾病、神经系统疾病、肺脏疾病、肾脏疾病的治疗都显示出其优越性,对心血管疾病治疗的研究也日益增多。目的:对骨髓间充质干细胞在心血管疾病中的应用以及治疗心血管疾病的机制进行综述。方法:应用计算机检索CNKI和Pubmed数据库中1985年1月至2009年12月关于骨髓间充质干细胞治疗心血管疾病的文章,在标题和摘要中以"骨髓间充质干细胞,细胞移植,治疗,心血管疾病"或"bone marrow mesenchymal stem cells,cells transplant,therapy,cardiovascular disease"为检索词进行检索,最终纳入42篇文献进行综述。结果与结论:众多的研究表明骨髓间充质干细胞可以在梗死的心肌中分化形成有功能活性的心肌、血管内皮等组织,改善心脏的功能,干细胞移植在治疗心血管疾病方面已表现出传统治疗方法所无可比拟的优越性。BACKGROUND： Bone marrow mesenchymal stem cells exhibit the capacity of multi-lineage differentiation and show advantages in treatment of liver disease, nervous system disease, lung disease and kidney disease. There are increasing studies regarding treatment of cardiovascular diseases.OBJECTIVE： To review the application of bone marrow mesenchymal stem cells in treatment of cardiovascular disease and the underlying mechanism. METHODS： A computer-based online retrieval was performed to search papers describing bone marrow mesenchymal stem cells for treatment of cardiovascular diseases published during 1985-01/2009-12 in CNKI and PubMed databases. The key words are bone marrow mesenchymal stem cells, cells transplant, therapy, cardiovascular disease. Forty-two papers were included in the final analysis. RESULTS AND CONCLUSION： A large number of studies have demonstrated that bone marrow mesenchymal stem cells can differentiate into functional cardiac tissue and vascular endothelial tissue in infarct tissue and improve cardiac function. Bone marrow mesenchymal stem cells show superiority over conventional therapy in the treatment of cardiovascular diseases.

关 键 词：干细胞 干细胞综述 心血管疾病 骨髓间充质干细胞 细胞移植 治疗 省级基金 

分 类 号：R318[医药卫生—生物医学工程]