种植体周围龈沟液高迁移率族蛋白B1的水平  

High mobility group box 1 protein level in peri-implant crevicular fluid

作　　者：刘金盼[1] 王明国[2] 李静[1] 杨世茂[3] 

机构地区：[1]潍坊医学院口腔医学院,山东省潍坊市261053 [2]济南市中心医院口腔科,山东省济南市250013 [3]山东大学口腔医学院,山东省济南市250012

出　　处：《中国组织工程研究》2013年第3期440-444,共5页Chinese Journal of Tissue Engineering Research

摘　　要：背景:近来研究发现高迁移率族蛋白B1在各种炎症中作为一种重要的炎症因子发挥了明显作用。目的:测定种植体周围黏膜炎患者龈沟液中高迁移率族蛋白B1的水平,探讨高速泳动族蛋白B1与种植体周围黏膜炎的关系。方法:选择健康种植体(n=39)、轻度种植体周围黏膜炎(n=24)和中度种植体周围黏膜炎(n=16)患者,测定种植体周围龈沟液量、龈沟液中高速泳动族蛋白B1总量及浓度;同时检测种植体周围黏膜炎的牙龈指数、菌斑指数、探诊深度和松动度。结果与结论:轻度种植体周围黏膜炎组龈沟液量、高迁移率族蛋白B1总量和浓度高于健康种植体组(P<0.01),但低于中度种植体周围黏膜炎组(P<0.01)。牙龈指数与龈沟液量之间存在正相关关系(P<0.01),牙龈指数、菌斑指数与高迁移率族蛋白B1总量及浓度存在正相关关系(P<0.01),探诊深度、松动度与高迁移率族蛋白B1浓度及总量间无明显相关性(P>0.05)。表明种植体周围龈沟液量及龈沟液中高迁移率族蛋白B1水平与种植体周围黏膜炎的病变程度有关,检测龈沟液中高速泳动族蛋白B1水平可作为临床诊断种植体周围黏膜炎的客观指标。BACKGROUND： Recent studies have found that high mobility group box 1 protein （HMGB-1） as an important inflammatory factor plays a significant role in various inflammations.OBJECTIVE： To determine the HMGB-1 level in the peri-implant gingival crevicular fluid and to investiage the correlation of HMGB-1 and peri-implant mucositis.METHODS： Patients with healthy implant （n=39）, with mild peri-implant mucositis （n=24） and moderate peri-implant mucositis （n=16） were enrolled. The amount of peri-implant gingival crevicuiar fluid, total amount of HMGB-1 and levels of HMGB-1 were detected. Clinical parameters were measured to investigate their relationships, including gingival index, mobility, plaque index, probing depth.RESULTS AND CONCLUSION： The amount of peri-implant gingival crevicular fluid, total amount of HMGB-1 and levels of HMGB-1 were significantly higher in the patients with mild peri-implant mucositis than in the healthy implant patients （P 〈 0.01）, but lower than the moderate peri-implant mucositis patients （P 〈 0.01 ）, Gingival crevicular fluid volume was positively correlated with gingival index and plaque index （P 〈 0.01 ）. The total amount of HMGB-1 was positively correlated with gingival index and probing depth （P 〈 0.01 ）. No significant difference was found between probing depth and mobility and the level and total amount of HMGB-1. This investigation show that HMGB-1 level in the gingival crevicular fluid may be as a diagnostic marker for peri-implant mucositis.

关 键 词：生物材料 组织工程口腔材料 高迁移率族蛋白B1 种植体周围黏膜炎 临床指标 相关性 

分 类 号：R318[医药卫生—生物医学工程]