新疆地区肺结核病人甲、乙、丙3型病毒性肝炎分布特征分析  

Analysis on the distribution characteristics of three types of viral hepatitis A,B and C among TB patients in Xinjiang province

作　　者：曾艳华[1] 向阳[2] 袁率[1] 吉萍[1] 袁仁术[1] 赵舒祺[1] 

机构地区：[1]新疆医科大学医学工程技术学院,乌鲁木齐830011 [2]新疆医科大学公共卫生学院,乌鲁木齐830011

出　　处：《新疆医科大学学报》2013年第3期334-339,共6页Journal of Xinjiang Medical University

基　　金：国家自然科学基金(30960328);新疆医科大学第六期大学生创新性实验计划项目(CX2011045)

摘　　要：目的了解肺结核病患者甲、乙、丙3型病毒性肝炎的分布特征,为在肺结核病人中开展甲、乙、丙3型病毒性肝炎知识宣传教育和干预工作提供参考依据。方法收集新疆部分地区肺结核患者的一般资料,采集血清,用酶联免疫吸附(ELISA)法检测甲肝抗体IgM(抗HAV-IgM)、丙肝抗体IgG(抗HCV-IgG)以及乙肝(HBV)抗原抗体系统3项血清学指标即乙肝标志物(HBV-M):乙肝表面抗原(HBsAg)、表面抗体(抗-HBs)和核心抗体(抗-HBc),并对其进行分析。结果采集肺结核病患者有效血清标本共1 355份,各指标阳性率分别为抗-HAV5.46%、抗-HCV3.47%、HBsAg6.64%、HBV感染率55.06%。北疆各指标抗HAV-IgM(5.99%)、抗HCV-IgG(5.58%)、HBsAg(10.74%)、HBV感染(63.02%)的阳性率均高于南疆[抗HAV-IgM(5.17%)、抗HCV-IgG(2.30%)、HBsAg(4.36%)、HBV感染(50.63%)],除抗HAV-IgM外,差异均有统计学意义。男性各指标抗HAV-IgM(6.87%)、抗HCV-IgG(4.71%)、HBsAg(7.25%)、HBV感染(56.36%)阳性率均高于女性(抗HAV-IgM(3.51%)、抗HCV-IgG(1.76%)、HBsAg(5.80%)、HBV感染(53.25%)),除HBsAg和HBV感染外,抗HAV-IgM和抗HCV-IgG阳性率差异有统计学意义。≥65岁组与<65岁组相比,抗HAV-IgM阳性率差异有统计学意义(χ2=6.64,P<0.05);HBsAg和HBV的阳性率均以65～75岁组最高(8.43、64.04%);抗HCV-IgG阳性率以25～35岁组最高(6.69%),各年龄组差异有统计学意义(χ2=12.524,P=0.028)。除抗HCV-IgG外,不同民族间抗HAV-IgM、HBsAg和HBV的阳性率差异有统计学意义(P<0.05);抗HAV-IgM阳性率其他民族最高(13.92%);HBsAg和HBV的阳性率汉族最高(12.5%、77.98%);抗HCV-IgG阳性率哈萨克族最高(6.90%)。结论肺结核病人甲、丙型病毒性肝炎检出率均较一般人群高,汉族和维吾尔族乙型病毒性肝炎检出率均高于相应的一般人群。甲、乙、丙3型病毒性肝炎检出率男性均高于女性,北疆高于南疆。≥65岁组的肺结核病人比<65岁组更容易罹患甲肝和乙肝;丙肝在25～35�Objective To know about the distribution characteristics of three types of viral hepatitis A, B and C among tuberculosis （TB） patients in parts of xinjiang province. Methods A study was conducted on TB patients in parts of Xinjiang province. Demographic information and blood samples were collected. Ser- um were tested for hepatitis A antibody-IgM （anti-HAV-IgM） and hepatitis C antibody-IgG （anti-HCV- IgG） using ELISA, besides serologic markers of hepatitis B. surface antigen （HBsAg）, surface antibody （anti-HBs） and core antibody （anti-HBc） were detected, then analyze these datum. Results Laboratory data were available for 1 355 participants in TB patients. The positive rate of anti-HAV, anti-HCV, HB- sAg and infection of HBV were 5. 46%, 3.47%, 6.64% and 55.06 respectively. The positive rates of all indicators in north of Xinjiang were higher than the south （anti-HAV.. 5. 99% vs 5. 17%, anti-HCV： 5.58% vs 2.30%, HBsAg. 10.74% vs 4.36%, infection of HBV. 63.02% vs 50.63%）. Differences were statistically except anti-HAV. High positive rate of all indicators were noticed in males than females （anti HAV. 6.87% vs 3.51%, anti-HCV. 4.71% vs 1.76%, HBsAg： 7.25% vs 5.80%, infection of HBV. 56.36% vs 53.25%）. Anti-HAV and anti-HCV positive rate were significant different except HBsAg and infection of HBV. Anti-HAV positive rate was different in ~65 age group and ~65 age group （;t2 =6.64, P d0.05）. The HBsAg positive rate and infection of HBV were the highest in 65~75 age group （8.43, 64.04%）. The anti-HCV was different in each age group （X2 =12. 524, P =0. 028） and the highest in 25 -35 age group. There was a meaningful difference of all positive rate except anti-HCV among every ethnic group. The highest positive rate of each indicators was the others in anti-HAV （13.92%）, Han in HBsAg （12.5%） and HBV （77.98%）, Kazak in anti-HCV （6.90%） res the positive rates of viral hepatitis A and C among TB patients are pectively. Conclusion The results show higher than t

关 键 词：肺结核病 甲型病毒性肝炎 乙型病毒性肝炎 丙型病毒肝炎 分布特征 

分 类 号：R512.6[医药卫生—内科学]