多项生化检测指标与2型糖尿病微血管病变的相关性研究  

Relationship Between Multiple Biochemical Indicators and Type 2 Diabetic Microangiopathy

作　　者：张春雪[1] 常向云[1] 孙侃[1] 叶婷[1] 种琨瑛[1] 

机构地区：[1]新疆石河子大学医学院第一附属医院内分泌科,新疆石河子832000

出　　处：《医学临床研究》2013年第2期284-286,共3页Journal of Clinical Research

摘　　要：【目的】探讨血清胱抑素C（Cysc）、糖化血红蛋白（HbAlc）、超敏c反应蛋白（hs—CRP）等生化指标与2型糖尿病（T2DM）微血管病变的关系。【方法】选择本院内分泌科住院患者及门诊正常体检者265例，其中正常人（NC）65例，糖尿病合并微血管病变（DMA）者100例，糖尿病无微血管病变（NDMA）者100例，分别测定其CysC、HbAlc、hs—CRP及血脂等生化指标，并测定一般临床资料，记录年龄、病程、血压、体重指数等。【结果1T2DM患者外周血中空腹血糖（FBG）、餐后两小时血糖（2hPG）、低密度脂蛋白（LDL）、HbAlc、CysC、hs—CRP浓度较NC组显著增高（P〈0．05），且DMA组患者外周血2hPG、HbAlC、甘油三脂（TG）、CysC、hs—CRP浓度明显高于NDMA组（P〈0．05）。DMA与血清CysC、2hPG、HbAlC、hs—CRP、年龄、病程相关（P〈0．05）。多元Logistic回归分析显示仅年龄、病程、HbAlC、hs—CRP是DMA的危险因素。【结论】DMA的发生、发展除与年龄、病程等因素相关外，还与HbAlC、hs—CRP有关。[Objective] To explore the relationship of biochemical indicators Cystatjn C （CysC）, glycosylated hemoglobin（HbAlc） and high sensitivity C-reactive protein（hs-CRP） with Type 2 diabetic microangiopathy （DMA）. [Methods]Totally 100 cases of DMA, 100 cases of diabetes mellitus without microangiopathy（NDMA） and 65 normal controls（NC） in endocrinological department of our hospital were chosen. The biochemical indica- tors such as CysC, HbAlc, hs-CRP and blood lipids were measured. The common clinical data were analyzed. The age, course, blood pressure and body mass index were recorded. [Results] Fasting blood glucose（FBG）, postprandial 2h blood glucose（2hPG）, low density lipoprotein（LDL）, HbAlc, Cys C and hs-CRP in peripheral blood of patients with type 2 diabetes mellitus were significantly higher than those in NC group（ P 〈0.05）. The 2hPG, HbAlc, triglyceride（TG）, Cys C and hs-CRP in peripheral blood of DMA group were significantly higher than those of NDMA group（P^0.05）. DMA was positively correlated with Cys C, 2hPG, HbAlc, hs-CRP, age and course（ P〈.05）. Multiple logistic regression analysis showed that only age, course, HbAlc and hs-CRP were the risk factors of DMA. [Conclusion] Not only the pathogenesis and development of DMA are related with the course and age, but also associated with HbAlc and hs-CRP.

关 键 词：糖尿病 2型 糖尿病血管病变 

分 类 号：R587.1[医药卫生—内分泌]