紫外分光光度法测定原料药中阿帕替尼的含量  

Determination of Apatinib in Raw Materials by Ultraviolet Spectrophotometry

作　　者：杜秋江[1] 

机构地区：[1]连云港职业技术学院医药与化工学院,江苏连云港222006

出　　处：《淮海工学院学报（自然科学版）》2013年第1期38-40,共3页Journal of Huaihai Institute of Technology:Natural Sciences Edition

摘　　要：采用紫外分光光度法测定原料药中阿帕替尼的含量。实验结果表明,阿帕替尼质量浓度在0～30μg/mL范围内服从比尔定律,其回归方程为A=0.041 4ρ(μg/mL)+0.010 6,线性相关系数R为0.999 8。该方法简便、快速,用于原料药中阿帕替尼含量的测定,测定结果与HPLC法测定结果一致。Apatinib in raw materials was determined by the ultraviolet spectrophotometric meth- od. Beer＇s law was obeyed in the apatinib concentration range of 0-30μg/mL with the regres- sive equation of A-----0.041 4p（μg/mL）＋0. 010 6 and the coefficient R of 0. 999 8. The method was simple and rapid, and the results obtained were in agreement with those of HPLC method.

关 键 词：紫外分光光度法 阿帕替尼 含量测定 

分 类 号：R917[医药卫生—药物分析学]