Impact of Solid / Vapour Equilibria on Conditions of Crystallization of Pharmaceutical Compounds  

作　　者：Cartigny Yohann Coquerel Gerard 

机构地区：[1]Laboratory of Separative methods and Sciences, Crystallogenesis Unit, University of Rouen

出　　处：《Transactions of Tianjin University》2013年第1期53-57,共5页天津大学学报（英文版）

摘　　要：The influence of solvent (in its gaseous state) on the stability of crystallized organic compounds was investigated. Through two examples of studies on the solid/vapour equilibria made in our lab, several behaviors were highlighted: (i) a new hydrated phase (thermodynamically stable) of an active pharmaceutical ingredient (API) was detected after the recrystallization starting from a deliquescent state, (ii) a spontaneous resolution of a hydrated racemic compound towards an anhydrous conglomerate can occur during the desolvation under the precise conditions of temperature and humidity. This study illustrates that knowledge about solid/vapour equilibrium is a crucial step during the complete characterization of solid organic compounds.The influence of solvent （in its gaseous state） on the stability of crystallized organic compounds was investigated. Through two examples of studies on the solid/vapour equilibria made in our lab, several behaviors were highlighted： （i） a new hydrated phase （thermodynamically stable） of an active pharmaceutical ingredient （API） was detected after the recrystallization starting from a deliquescent state, （ii） a spontaneous resolution of a hydrated racemic compound towards an anhydrous conglomerate can occur during the desolvation under the precise conditions of temperature and humidity. This study illustrates that knowledge about solid/vapour equilibrium is a crucial step during the complete characterization of solid organic compounds.

关 键 词：solid/vapour equilibria  hydrates  deliquescence  pharmaceutical solids  dynamic vapour sorption 

分 类 号：TQ460.1[化学工程—制药化工]