基于多波长数字锁相检测的光学拓扑成像方法  

Methodology on Optical Topographic Mapping Based on Multi-Wavelength Lock-in Detection

作　　者：高峰[1,2] 朱苹苹[1] 易茜[1] 张伟[1] 陈琛[1] 张丽敏[1,2] 

机构地区：[1]天津大学精密仪器与光电子工程学院,天津300072 [2]天津市生物医学检测技术与仪器重点实验室,天津300072

出　　处：《天津大学学报》2013年第2期162-167,共6页Journal of Tianjin University(Science and Technology)

基　　金：国家自然科学基金资助项目(30970775;81101106;61108081);国家高技术研究发展计划(863计划)资助项目(2009AA-02Z413);天津市自然科学基金重点资助项目(10JCZDJC17300);教育部博士点新教师基金资助项目(20100032120064)

摘　　要：光学拓扑成像方法作为现有脑功能成像模态极为有益的补充,可量化脑组织中血红蛋白的氧合状况,对临床诊断和治疗工作有着非常重要的意义.但目前已推出的光学拓扑成像系统价格昂贵,较难推广,为此设计了一种结构简单、成本较低的基于数字锁相检测技术的光学拓扑成像系统,目的是以设定的源-探测光纤阵列,量化组织体浅层区域的血红蛋白浓度的变化.该系统将两路不同波长的激光信号耦合后作为辐射光源,以数字锁相技术同步检测输出光强;并以修正的Beer-Lamber定律为模型计算每对相邻的源-探测光纤处大脑皮层活动前后血红蛋白的浓度变化量.Optical topographical imaging has been regarded as the most beneficial supplement to the other established methods used in the functional mapping of human cerebral cortex. Also, quantifying the changes in cerebral oxygena- tions plays a great role in clinical diagnosis and treatment. Now the existing optical topographic mapping system is too expensive to be popularized. Thus, a dual-wavelength optical topography system with low cost and simple structure is developed, aiming at quantifying the hemoglobin concentration changes in shallow tissue regions using the optode array. In this system, two laser beams with different wavelengths are combined and the signals are simultaneously detected using a digital lock-in technique. By applying the modified Beer-Lambert law to each adjacent source- detector pairs, the changes of hemoglobin concentration in the cerebral cortex caused by physiological or psychologi- cal activities can be calculated.

关 键 词：光学拓扑 数字锁相检测 血红蛋白浓度 

分 类 号：Q63[生物学—生物物理学]