母源性免疫传递在增强乙肝疫苗免疫应答水平中的作用  

Study on higher immune response after injection of HBV vaccine in infants by transmission from a novel level of HBsAb sourced mother

作　　者：白兴武[1] 刘金霞[2] 卢安[3] 李建团[4] 高杨[2] 王丽娜[2] 

机构地区：[1]承德护理职业学院 [2]承德医学院 [3]河北省疾病预防控制中心 [4]承德医学院附属医院,河北承德067000

出　　处：《临床和实验医学杂志》2013年第6期407-408,共2页Journal of Clinical and Experimental Medicine

基　　金：河北省科技厅重大项目:项目编号:11276103D-2

摘　　要：目的通过定量检测婴幼儿和母亲血清HBsAb水平,观察母亲HBsAb水平对婴幼儿儿主动免疫效果的影响,探讨母源性免疫传递在增强乙肝疫苗免疫应答水平中的作用。方法①选择185例母亲和其生产的191例婴幼儿,按标准剂量和程序分别给予新生儿注射乙肝疫苗;②在新生儿8～48个月时,分别检测母亲和婴幼儿血清HBsAb水平③分析婴幼儿HBsAb水平与母亲体内HBsAb水平相关性。结果婴幼儿HBsAb水平与母亲体内HBsAb水平有显著相关性(P<0.05)。结论可以通过母源性免疫传递,提高乙肝疫苗注射后HBsAb阳转率,提高婴幼儿乙肝疫苗注射后免疫效果。Objective To observe the effect of active immunization on infants by quantitative detection of serum levels of HBsAg in mother and infants, and to explore the contribution that maternal immunity transmission can enhance the level of immunological response. Methods （1） A total of 185 mothers and 191 infants were injected with HBV vaccine according to standard dosage and program. （2） The serum levels of anti - HBs of mother and infants from 8 to 48 months after their birth were examined by ECLIA reagents for anti - HBs from Roche Diagnostics GmbH. （3） The relationship of serum levels of HBsAb between mothers and infants was analyzed. Results There was significant correlation in levels of HbsAb between mothers and infants. Conclusion The higher immune effectiveness after injection of HBV vaccine in infants by maternal immunity transmission has been found from a novel level of HBsAb sourced mother.

关 键 词：婴幼儿 母亲 HBSAB 免疫传递 乙肝疫苗 

分 类 号：R186[医药卫生—流行病学]