正常人体呼吸频率调节下血压即时变异与心率变异关系的研究  

Research on the relationship between blood pressure instant variability and heart rate variability of normal person under respiratory control

作　　者：沈仲元[1] Shin Lin 竺英祺[1] 余平[1] 郁伟林[1] 章琪虎[1] 瞿敏红[1] 

机构地区：[1]上海中医药大学气功研究所,上海200030 [2]美国加州大学尔湾生物学院,美国加州92697

出　　处：《江苏实用心电学杂志》2013年第1期486-491,共6页Journal of Practical Electrocardiology JS

基　　金：国家自然科学基金资助项目(81072853//H2717)

摘　　要：目的探讨人体呼吸频率调节下血压即时变异(blood pressure instant variability,BPIV)与心率变异(HRV)的关系。方法将52名健康受试者随机分为两组,分别在改变呼吸频率5-10-15次/min(A组,n=25)和8-12-16次/min(B组,n=27)的条件下,同步记录心电,血压和呼吸,并进行分析。结果在10-15次/min和8-12-16次/min不同频率的呼吸调节下,R-R变化趋势、血压-血压变化趋势和呼吸波变化趋势完全同步。呼吸频率/心搏频率与呼吸峰中心频率(RSP)、BPIV、HRV的中心频率的相关系数分别为0.924、0.902、0.913。在5次/min频率的呼吸调节下,R-R变化趋势、血压-血压变化趋势和呼吸波变化趋势出现了不同步现象。结论在一定呼吸频率调节下,BPIV符合呼吸性窦性心律不齐的生理机制,也符合呼吸性窦性心律不齐形成的心率变异机制,是RR间期变化的二次效应。但当呼吸频率过低的情况下,BPIV不符合呼吸性窦性心律不齐形成的心率变异机制。Objective To discuss the relationship between blood pressure instant variability （BPIV） and heart rate variability（HRV） of human under respiratory control. Methods Fifty-two healthy people＇s ECG, blood pressure （BP）and respiration were synchronously recorded and ana- lyzed when respiratory rate were controlled at 5-10-15 times/min and 8-12-16 times/min. Results At respiratory rate of 10-15 times/rain and 8-12-16 times/rain, R-R variation trend and BP-BP vari- ation trend were fully synchronized with respiratory wave variation trend. Correlation coefficients（r） of center frequency of RF/HR with peak of respiratory（RSP） , BPIV and HRV were 0. 924, 0. 902 and O. 913, respectively. At respiratory rate of 5 times/rain, R-R variation trend and BP-BP varia- tion trend were desynchronized. Conclusions At certain respiratory rate, BPIV is corresponded with the physiological mechanism of respiratory sinus arrhythmia and HRV mechanism caused by re- spiratory sinus arrhythmia. However, BPIV is not corresponded with the physiological mechanism of HRV mechanism caused by respiratory sinus arrhythmia when respiratory rate is too low.

关 键 词：呼吸频率调节 血压即时变异 血压变异 心率变异 呼吸性窦性心律不齐 

分 类 号：R540.4[医药卫生—心血管疾病]