羊的膜肺过程对头孢拉定药代动力学的影响  

Effect of extracorporeal membrane oxygenation on cefradine pharmacokinetics in sheeps

作　　者：黄伟雄[1] 宋国维[1] 甘小庄[1] 马广松[1] 李杰[1] 孙丽萍[1] 李惠[1] 

机构地区：[1]首都儿科研究所,北京100020

出　　处：《基础医学与临床》2000年第5期82-84,共3页Basic and Clinical Medicine

基　　金：卫生部!94-1-286;北京市科委!951851000

摘　　要：观察膜肺（ECMO）过程对羊头孢拉定药代动力学的影响。通过在ECMO 前和ECMO 中对8 只绵羊静注头孢拉定，观察药物在动物体内的分布和代谢情况。与ECMO 前自身对照比较，ECMO 中药动力参数表现为清除相半衰期（T 1/2 b）延长（38.1 6.1min vs 69.8 17.0min P<0.01）总表观分布容积（V d） 增大（0.30 0.12L/kg vs 0.46 0.18L/kg P<0.01），而清除率（Cl）等其它参数无明显改变。体外循环中膜氧合器前后头孢拉定血药浓度测定结果无任何差异。（1）ECMO 治疗过程并不影响药物清除率，清除相半衰期延长可能来源于体外循环所致的总表观分布容积增大。（2）膜氧合器本身对药物并无清除作用。To evaluate the potential influence of extracorporeal membrane oxygenation ECMO on cefradine pharmacokinetics The disposition of cefradine was studied in eight sheeps receivings a single iv dose of cefradine before and during ECMO therapy Estimates of elimination halflife T 1/2 b and apparent volume of distribution V d for cefradine were significantly increased during ECMO comparing with pre-ECMO values 38.1 6.1mins vs 69.8 17.5mins P<0.01 and 0.30 0.12L/kg vs 0.46 0.18L/kg P<0.01 respectively The clearance of cefradine was unaffected by the procedure Pared plasma cefradine concentrations obtained pre-and post-oxygenator demon- strated no increase removal of drug These data suggest that the prolonged T 1/2 b dring ECMO is duo to ECMO-induced increase in V d of cefradine and membrane oxygenator does not eliminate cefradine

关 键 词：膜肺 药代动力学 头孢拉定 羊 

分 类 号：R969.1[医药卫生—药理学] R978.11[医药卫生—药学]