头孢噻肟钠配伍稳定性考察  

Stability and Compatibility of Cefotaxime Sodium Combined with Other Seven Drugs

作　　者：王刚[1] 李德芬[1] 

机构地区：[1]重庆医科大学儿童医院,400014

出　　处：《医药导报》2000年第5期468-469,共2页Herald of Medicine

摘　　要：目的 :探明头孢噻肟钠与临床常用注射剂配伍的稳定性。方法 :摸拟临床用药条件 ,选择利巴韦林等 7种常用的注射剂 ,在pH 5 .0 ,10 %葡萄糖注射液中与其配伍 ,考察在 2 5℃ ,3 7℃ 8h内的稳定性。结果 :2 5℃时 ,放置时间对含量变化影响不显著 ,而药物配伍的影响较显著 ,3 7℃时 ,放置时间与配伍变化均对含量有较显著影响。结论 :混合液稳定性受温度、放置时间和pH的影响较显著 (P <0 .0 5 )。Objective:A stability and compatibility of cefotaxime sodium combined with other seven drugs were inspected.Methods:Using conditions of drugs in clinical were imitated, 7 kinds of drugs for injections and cefotaxime sodium were combined, respectively, dissolved with 10% glucose injection solution in the pH 5.0. The stability and compatibility were inspeted 8 h after combination at 25 ℃,37 ℃. Results:The setting time did not produce a significant influence to contend change at 25 ℃, while the drugs compatibleness had more significant influence at 37 ℃. Both of setting time and compatible change had more significant inflence to the contend. Conclusion:The stability of mixture occured significant changes with the changes of temperature, time of store, and pH (P<0.05)。

关 键 词：头孢噻肟钠 配伍 稳定性 实验研究 

分 类 号：R978.11[医药卫生—药品] R927.11[医药卫生—药学]