Ⅱ型糖尿病患者无症状心肌缺血与微量白蛋白尿的关系  

Relationship between asymptomatic myocardial ischemia and microproteinuria in type Ⅱ diabetes meuitus patients

作　　者：姜春艳[1] 张祥林[1] 禚敏 王笑英[2] 苏雪梅[2] 

机构地区：[1]吉化集团公司总医院,132022 [2]吉林省人民医院,130021

出　　处：《吉林医学》2000年第5期271-272,共2页Jilin Medical Journal

摘　　要：目的 :探讨 型糖尿病患者无症状心肌缺血与微量白蛋白尿之间的关系 ,以利于冠心病的早期预防和治疗。方法 :将存在微量白蛋白尿的 型糖尿病患者 5 0例做为研究组 ,另选年龄、性别、糖尿病病程与之相匹配的无微量白蛋白尿症的 型糖尿病患者 32例做为对照组 ,采用次极量的踏车运动试验 ,记录心肌缺血的发生率、运动时间、最大运动量、高峰心率。结果 :研究组与对照组比较 ,心肌缺血反应的发生率较高 (6 5 %对 42 % ,P <0 .0 5 ) ,平均运动时间较短〔(6 .8± 2 .1)对 (7.9± 2 .0 ) min,P<0 .0 1〕,最大运动心率亦较低 (115± 2 0次 / min对 12 7± 16次 / min,P<0 .0 1) ,运动量较低 (6 41± 2 18kg· m / min对 740± 2 11kg·m/ min,P<0 .0 1)。结论 :存在微量白蛋白尿的 型糖尿病患者发生无症状心肌缺血较常见 ,通常在较低的运动负荷下就可发生心肌缺血 。Objective To investigate the relationship between asymptomatic myocardial ischemia and microproteinuria in type Ⅱ diabetes meuitus(DM)patients for the purpose of earcier prevention and treatment of coronary heart disease(CHD).Method Secondary maximal exercise test of pedal was used to record the incidence rate of myocardial ischemia;time of exercise;the amount of maximal exercise and climax heart rate in 50 patients of type Ⅱ DM with microproteinuria as the 'Studied Group' and 32 patients of type Ⅱ DM without microproteinuria as the 'Compared Group'.Results Compared with 'Compared Group',the incidence rate of myocardial ischemia of Studied Group is much higher(65% vs 42%,P<0.05);the everage exercise time was shorter 〔(6.8±2.1)/min,VS(7.9±2.0)/min,P<0.01〕;the climax heart rate was lower(115±20/min VS 127±16/min,P<0.01);amount of exercise was lower(641±218kg·m/min vs 740±211kg·m/min.P<0.01).Conclusion The incidence of myocardial ischemia for the patients of type Ⅱ DM with microuproteinuria is very common,even in case of lower exercise load.There fore,the active and earler preventive measures for CHD shall be taken.

关 键 词：Ⅱ型糖尿病 无症状心肌缺血 微量白蛋白尿 

分 类 号：R587.1[医药卫生—内分泌] R541.4[医药卫生—内科学]