木尘提取液诱发体外培养BALBA/c-3T3细胞微核和多核  

Frequencies of Micronucleated and Multinucleated Cells in BALB/c -3T3 Cells in Vitro Induced by Wood Dust Extracts.

作　　者：何鹏[1] 吴德生[1] 董奇男[1] 

机构地区：[1]华西医科大学环境卫生学教研室,成都610041

出　　处：《中国公共卫生》2000年第10期896-897,共2页Chinese Journal of Public Health

基　　金：四川省卫生厅基金资助项目

摘　　要：为探讨木尘的诱变性 ,选择硬木和软木各一种 ,分别为榉木和桦木 ,制备成木尘水提取液和有机提取液 ,进行BALB/c 3T3细胞微核和多核诱导试验。结果显示榉木尘和桦木尘两种提取液均存在细胞毒性 ,并可引起BALB/c 3T3细胞微核和多核细胞率的明显升高 ,剂量反应关系成立。To study the mutagenicity of wood dust,BALB/c 3T3 cells were respectively treated with water′s and organic extracts of beech wood dust and birch wood dust in vitro,and the frequencies of micronucleated and multinucleated cells in BALB/c 3T3 cells were observed.The results showed toxicity and the frequencies of micronucleated and multinucleated cells in BALB/c 3T3 cells were significantly increased by all extracts,and a dose response relationship was observed.It indicated both extracts of beech wood dust and birch wood dust were mutagenic

关 键 词：木尘提取液 BALBA/c-3T3 细胞微核 多核 

分 类 号：R114[医药卫生—卫生毒理学]