富硒香菇活性多糖对实验大鼠免疫缺陷干预及其影响因素研究  

The Research on Se Lentinan's Intervention to SD Rat's Immunodeficiency

作　　者：赵美英[1] 蔡文德[2] 肖祖健[3] 

机构地区：[1]华中科技大学同济医学院,武汉430030 [2]深圳市卫生防疫站 [3]深圳市红十字会医院

出　　处：《中国公共卫生》2000年第10期901-902,共2页Chinese Journal of Public Health

基　　金：深圳市康美实业发展有限公司研究基金课题

摘　　要：为证明含富硒香菇多糖 (Se -LEN)对大鼠免疫调节及T细胞亚群增殖的提升作用 ,通过建立免疫缺陷模型 ,经Se-LEN干预 ,采用流式细胞术观察T细胞亚群等的变化。结果表明 :干预组对淋巴细胞、CD3+、CD4+的增殖有明显的促进作用 ,脾指数、胸腺指数明显增加。 1/ 5常剂量组上述结果低于对照 ,接近模型组。促进LYM增殖的起始时间于干预 1周后即可产生。提示 :Se -LEN具有增强细胞免疫调节功能 ,显著地促进CD4+增殖和提高CD4+/CD8+,常量组和 5倍剂量组有效、快速。To prove the Se Lentinan(Se-LEN)'s improve effect to the rat's immunity regulation and T lymphocyte subgroup,we observe the change of the T lymphocyte subgroup and so on through flow cytometer by building a immunodeficiency model with Se LEN's intervention.The results show that the intervene group had obviously improve effect to the proliferation of lymphocyte,CD3+,and CD4+.The spleen index and thymus index increased obviously.The 1/5 dose group's result was lower than control group,and similar to the model group,it promoted the beginning time of lymphocyte's proliferation occurred in one week after intervention.This prove Se LEN can prompt the regulating function of the cellular immunity,can remarkably prompt CD4's proliferation and increase CD4/CD8.The normal dose group is feasible ,fast and effective.

关 键 词：富硒香菇多糖 免疫缺陷 T细胞亚群 流式细胞术 

分 类 号：R979.5[医药卫生—药品] R593.3[医药卫生—药学]