异丁香酚的离体透皮吸收研究  

Study on the Permeability of Isoeugenol in Vitro

作　　者：周梅华[1] 刘静波[2] 

机构地区：[1]上海医科大学分析化学教研室,上海200032 [2]上海医科大学预防医学研究所

出　　处：《中国公共卫生》2000年第10期907-907,共1页Chinese Journal of Public Health

摘　　要：采用静态渗透室装置 ,测定异丁香酚皮片涂药后不同时间对小鼠离体皮肤透皮吸收率 ,异丁香酚采用GC法测定 ,结果 :异丁香酚经离体小鼠皮肤的渗透率随时间的增加而增加 ,2 4h后 ,异丁香酚的渗透率为 1 0 0 %。结论To study the permeability of isoeugenol through skins of mice in vitro.A static glass diffusion cell system was used.Samples were collected at different time after the isoeugenol was applied.The concentration of isoeugenol in the samples was measured by GC.It showed that the permeabilities of isoeugenol through skins of mice gradually increased within the experiment time.The permeabilities of isoeugenol through the skins of mice at 24h post application was 1 00% The result showed that isoeugenol may be absorbed through skins of mice in vitro after it is applied.

关 键 词：异丁香酚 气相色谱 离体透皮吸收 

分 类 号：R944.9[医药卫生—药剂学]