心脏病患者心功能与心包液中心钠素和内皮素浓度的关系  

Effect of cardiac function on concentrations of ANF and ET-1 in pericardial fluid of patients with heart disease

作　　者：温绍君[1] 王耀宏[1] 王卫梅[1] 房芳[1] 文杰[1] 王金城[1] 张忱[1] 张维君[1] 左大鹏[1] 

机构地区：[1]北京市心肺血管疾病研究所首都医科大学附属北京安贞医院,100029

出　　处：《中华心血管病杂志》2000年第5期377-378,共2页Chinese Journal of Cardiology

基　　金：北京市青年基金; 北京市重点学科资助

摘　　要：目的　探讨心脏病患者心包液内皮素 (ET 1)、心钠素 (ANF)与心脏功能的关系。方法　 45例行心脏手术的心脏病患者 ,均按NYHA标准评价心功能并在心包切开前同时取心包液及静脉血 ,按放免分析法测定ANF、ET 1浓度。结果　 (1)心包液中存在具有免疫活性的ANF和ET 1,二者在心包液中的浓度均显著高于其血浆中的浓度 (P <0 0 1) ;(2 )心包液ET 1与心功能呈负相关 (r=- 0 49,P =0 0 0 1) ;(3)心包液ANF浓度与心功能呈正相关 (r=0 6 5 2 ,P <0 0 1) ;与心胸比例极显著相关 (r =0 5 86 ,P =0 0 0 1)。结论　心脏病患者心包液ANF及ET 1浓度与心脏功能密切相关。Objective To investigate the relationship between cardiac function and ANF and ET 1 levels in the pericardial fluid (PF) of patients with heart disease. Methods Forty five patients with heart disease underwent cardiac surgery were studied. PF and venous blood samples were taken before pericardiotomy. ET 1 and ANF levels were measured by RIA. Result (1) Both ir ANF and ir ET levels in the PF were found significantly higher than those in the serum ( P< 0 01). (2) ET 1 level in the PF was negatively relevant to the cardiac function (r= -0 49, P= 0 001). (3) ANF level in the PF was positively relevant to the cardiac function (r= 0 652, P< 0 01), and it was also significantly relevant to the ratio of heart to chest (r= 0.586, P= 0 001). Conclusion ANF and ET 1 levels are closely related to the cardiac function in patients with heart disease.

关 键 词：心脏病 心功能 心包液 心钠素 内皮素 

分 类 号：R541[医药卫生—心血管疾病]