Limb Muscle Hemodynamics and Arterial Distensibility Depend on Atmospheric Pressure in Hypertensive Men  

作　　者：Vladimir N.MELNIKOV Sergey G.KRIVOSCHEKOV Tamara G.KOMLYAGINA Svetlana Y.RECHKINA Nathan S.CONSEDINE 

机构地区：[1]Institute of Physiology,Siberian Branch of the Russian Academy of Medical Sciences,Novosibirsk,630117,Russia [2]Sanatorium "El'tsovka," Novosibirsk,Russia [3]Department of Psychological Medicine,University of Auckland,New Zealand

出　　处：《Biomedical and Environmental Sciences》2013年第4期284-294,共11页生物医学与环境科学（英文版）

摘　　要：Objective To verify whether peripheral blood circulation and arterial wall distensibility are influenced by atmospheric pressure （AtPr） and to examine if their association is dependent on age and/or sex. Methods Associations among natural AtPr levels （on the examination day as well as 1 and 2 days prior）, limb muscle hemodynamics, and distensibility of conduit arteries were retrospectively examined in an observational study of 276 untreated patients with primary moderate hypertension （mean age 56.4 years, 194 men）. Forearm and calf circulations at rest and 3 min after ischemia were measured by venous occlusion plethysmography. Compliance of the brachial and shank arteries was assessed by oscillometry. Results After adjustment for age, degree of hypertension, and season, correlation and multiple resression analyses revealed a season-independent but age-dependent direct correlation between the stiffness of limb arteries and AtPr levels on the examination day in men, but not women. The association weakened with the degree of hypertension, disappeared with age, and was more evident in the arms than in the legs. Conclusion Parameters of arterial wall distensibility in adult hypertensive men are susceptible to AtPr changes within the usually observed limits （730-770 mmHg）. It is proposed that reduction of arterial wall barometric responsiveness in women and aging men is a likely mechanism underlying their meteosensitivity.Objective To verify whether peripheral blood circulation and arterial wall distensibility are influenced by atmospheric pressure （AtPr） and to examine if their association is dependent on age and/or sex. Methods Associations among natural AtPr levels （on the examination day as well as 1 and 2 days prior）, limb muscle hemodynamics, and distensibility of conduit arteries were retrospectively examined in an observational study of 276 untreated patients with primary moderate hypertension （mean age 56.4 years, 194 men）. Forearm and calf circulations at rest and 3 min after ischemia were measured by venous occlusion plethysmography. Compliance of the brachial and shank arteries was assessed by oscillometry. Results After adjustment for age, degree of hypertension, and season, correlation and multiple resression analyses revealed a season-independent but age-dependent direct correlation between the stiffness of limb arteries and AtPr levels on the examination day in men, but not women. The association weakened with the degree of hypertension, disappeared with age, and was more evident in the arms than in the legs. Conclusion Parameters of arterial wall distensibility in adult hypertensive men are susceptible to AtPr changes within the usually observed limits （730-770 mmHg）. It is proposed that reduction of arterial wall barometric responsiveness in women and aging men is a likely mechanism underlying their meteosensitivity.

关 键 词：Atmospheric pressure Arterial stiffness Compliance Venous circulation AGE-DEPENDENCE Sex difference Season 

分 类 号：R544.1[医药卫生—心血管疾病]