海星甾醇对血小板聚集的药理研究  

The Effects of Starfish Sterol on Platelet Aggregation

作　　者：许东晖[1] 许实波[1] 

机构地区：[1]中山大学药学系,广州510275

出　　处：《中药材》2000年第10期627-630,共4页Journal of Chinese Medicinal Materials

基　　金：国家"九五"重点科技攻关项目(编号96-C02-04-01)

摘　　要：通过大鼠、大白兔体内、体外血小板聚集实验,评价海星甾醇对大鼠体外实验性血栓形成及经花生四烯酸(AA)、ADP、CaCl_2诱导血小板聚集的药理作用。海星甾醇po4.5、13.5、4O.5mg/kg对大鼠体外实验性血栓的抑制率分别为10.0％、20.1％、25.9％(P<0.01),同时能够抑制经AA、ADP、CaCl_2诱导的血小板聚集(P<0.001),提示海星甾醇具有抑制血小板聚集作用。Through the internal and external experiments of platelet aggregation on rats and rabbits, we study the effcets of starfish sterol (No.A1998) on the formation of experimental thrombus in vitro and the effects of pktelet aggregation induced by arachidonic acid (AA), ADP, CaCl2 . Starfish sterol A 1998 can inhibit the fonnation of experimental thrombus in vitro of rats on the rates of 10.0% ,20.1% ,25.9%(P< 0.01) ,po starfish sterol4.5,13.5,40.5 mg/kg. A 1998 can inhibit platelet aggregation induced by AA,ADP,CaCl2 in the same time.It can be concluded that starfish sterol has inhibitory effects on platelet aggregation.

关 键 词：海星甾醇 血小板聚集 药理研究 

分 类 号：R973.2[医药卫生—药品]