糖调节受损患者血浆sEPCR,sTM,vWF水平变化的研究  

Research on the Level Change of Plasma sEPCR,sTM,vWF under the State of IGR

作　　者：廖国玲[1,2] 杨风琴[1,2] 杨华[1,2] 

机构地区：[1]宁夏医科大学检验学院 [2]宁夏医科大学医学检验研究所

出　　处：《现代检验医学杂志》2013年第1期77-78,82,共3页Journal of Modern Laboratory Medicine

基　　金：宁夏医科大学＂博士学位建设学科＂开放课题（KF2010-46）.

摘　　要：目的 探讨血浆蛋白C受体（sEPCR）、可溶性血栓调节蛋白（sTM）、血管性血友病因子（vWF）在糖调节受损状态下的变化.方法 采用双抗夹心ELISA法检测60例健康人（对照组）和59例糖调节受损患者的血浆sEPCR,sTM和vWF.结果 空腹血糖受损患者血浆sEPCR,sTM和vWF含量分别为120.92±24.46 μg/L,19.94±5.08 μg/L和99.13±14.78 U/L,高于对照组（117.28±20.27 μg/L,18.09±6.37 μg/L,98.12±10.70 U/L）,t为1.98,P〈0.05,差异无统计学意义;糖耐量减退患者血浆sEPCR,sTM和vWF含量分别为126.34±28.52 μg/L,21.61±7.60 μg/L和106.02±22.85 U/L,较对照组显著增高,t为0.952,P〈0.01,差异具有统计学意义.经相关分析,血浆sEPCR,sTM和vWF与空腹血糖水平呈正相关（r=0.89,P〈0.01;r=0.55,P〈0.01;r=0.88,P〈0.01）.结论 随糖调节受损的发生发展,血浆sEPCR,sTM和vWF水平随之也增高,血浆sEPCR,sTM和vWF变化可能为糖尿病血管并发症的预测提供依据.Objective This paper discusses the plasma sEPCR,sTM,vWF in patients under the state of IGR. Methods This paper detected the levels of sEPCR,sTM and vWF in the plasma of 60 normal persons （control group） and 59 cases of patients under the state of IGR plasma by double antibody sandwich ELISA assay. Results The study showed the levels of sEPCR, sTM and vWF in plasma of IGT group were higher than those in normal control group. The content of sEPCR,sTM and vWF were 120.92 ± 24.46 μg/L, 19.94 ±5.08 μg/L and 99.13 ±14.78 U/L, respectively. Their difference was not statistically significant（t= 1.98,P〈0. 05） ,but the plasma sEPCR, sTM and vWF in IFG group was significantly higher. The content of sEPCR,sTM and vWF were 126.34±28.52 μg/L, 21. 61±7.60μ g/L and 106.02±22.85 U/L,respectively. Their difference was statistically significant （t = 0. 952, P〈0.01）. Through correlation analysis, plasma sEPCR, sTM and vWF and fasting plasma glucose levels were positively related to （r = 0.89, P〈 0. 01 r = 0.55, P 〈 0.01 r = 0.88, P 0. 01）. Conclusion With the state of IGR increased gradually,the plasma sEPCR,sTM and vWF levels also increased,leading to diabetic vascular complications and development, sEPCR,sTM and vWF may be the early predictive indexes of diabetic complications.

关 键 词：血管性血友病因子 蛋白C受体 可溶性血栓调节蛋白 糖调节受损 

分 类 号：R587.1[医药卫生—内分泌] R392.11[医药卫生—内科学]