昆明地区健康成人血红蛋白及相关指标的参考区间调查  

Investigation of Reference Intervals of Hemoglobin and Related Tests Within Healthy Adult Individuals in Kunming

作　　者：尹利民[1] 饶迪[2] 贾蔚[2] 胡大春[1] 

机构地区：[1]昆明市第一人民医院检验科,昆明650011 [2]昆明市第一人民医院体检中心,昆明650011

出　　处：《现代检验医学杂志》2013年第1期79-82,共4页Journal of Modern Laboratory Medicine

摘　　要：目的 建立昆明地区健康成人血红蛋白（HGB）及相关指标的生物参考区间.方法 按照美国临床和实验室标准协会（CLSI） C28-A2文件推荐的间接抽样法,选取了2010年5月～2011年3月的健康体检者共10 970例（男性6 076例,女性4 894例）,年龄18～80岁,用Sysmex XS-800i对HGB及相关指标进行检测,用Stata 11对检测结果进行统计分析.结果 分别按性别和年龄进行分组,计算HGB及相关指标的参考区间.各项指标的参考区间（P2.5～P97.5）如下：HGB男性为146～187 g/L,女性为120～161g/L;红细胞计数（RBC）男性为（4.69～6.35）×1012/L,女性为（4.16～5.58）×1012/L;红细胞平均血红蛋白浓度（MCHC）男性为318～355 g/L,女性为309～346 g/L;红细胞压积（HCT）男性为43.8%～55.3%,女性为37.7%～49.0%.不同性别组的HGB及相关指标的参考区间经Z检验分析,需分别给出;而不同年龄组的参考区间经Z检验可予以合并.结论 昆明地区HGB及相关指标的参考区间明显高于以往采用的参考区间,因此建立或验证该实验室HGB的生物参考区间非常必要.Objective To establish the biological reference intervals of hemoglobin and related tests within healthy adult individuals in Kunming. Methods According to the indirect sampling technique in Clinical and Laboratory Standards Institute （CLSI） C28-A2,hemoglobin and related tests of 10 970 healthy individuals （6 076 male,4 894 female;aged 18-80 y） were determined by Sysmex XS-800i from May 2010 to March 2011. The test results were statistical analysis by Stata 11. Results Grouped by sex and age,the reference intervals of hemoglobin and related tests were calculated. The reference intervals （P2.5 -P97.5 ） were showed as follows： HGB 146-187 g/L（male） and 120-161 g/L（female） ,RBC （4. 69-6.35） × 10^12/L （male） and （4. 16-5.58）× 10^12/L（female）, MCHC 318-355 g/L（male） and 309-346 g/L（female）, HCT 43.8-55.3 % （male） and 37.7-49.0% （female）, respectively. The reference intervals of different sex for HGB and related tests should exist by z-test,but those of different age should be combined. Conclusion The reference intervals of HGB and related tests were significantly higher than that used in the past in Kunming. So it is necessary to establish or verify the biological reference intervals of hemoglobin and related tests.

关 键 词：血红蛋白 参考区间 昆明 

分 类 号：R446.111[医药卫生—诊断学]