脂必泰和辛伐他汀降脂及消褪颈动脉斑块疗效的对比研究  

Comparison of Zhibitai and Simvastatin in hypolipemic effect and atheromatous plaque resolution of carotid artery in patients with hyperlipemia

作　　者：周慧[1] 杨海芸[1] 张佳卉[1] 

机构地区：[1]上海交通大学医学院附属仁济医院普内科,上海200127

出　　处：《中国现代医学杂志》2012年第35期64-68,共5页China Journal of Modern Medicine

摘　　要：目的比较中药脂必泰和辛伐他汀在降脂及消褪颈动脉斑块等方面的疗效,并了解其临床应用的安全性。方法选择血脂异常的139例患者,年龄40～75岁,随机分为脂必泰组(240 mg,2次/d,n=69)和辛伐他汀组(20 mg/d,n=70)。分别于治疗前及治疗后3、6和12个月检测血脂、肌酸激酶及肝肾功能,并于治疗前及治疗后12个月行颈动脉多普勒超声检查。结果与治疗前比较,治疗3、6和12个月后,两组高脂血症患者胆固醇、三酰甘油、低密度脂蛋白均显著下降(P<0.05),高密度脂蛋白显著升高(P<0.05)。两组治疗前后肝肾功能、肌酸激酶变化差异无统计学意义(P>0.05)。与治疗前比较,两组治疗12个月后,颈动脉内膜厚度均减少(P<0.01),血流速度增加(P<0.01),颈动脉斑块最大横截面积减小(P<0.01),两组间比较差异无统计学意义(P>0.05)。结论中药脂必泰能有效降低血脂和消褪颈动脉斑块,疗效与辛伐他汀相似,且临床应用安全。[Objective] To compare the effects of Zhibitai versus Simvastatin on lipid-lowering and atheromatous plaque resolution of carotid artery in patients with hyperlipemia. [Methods] A total of 139 pa- tients with hyperlipemia were randomly divided into Zhibitai group （n =69） and Simvastatin group （n =70）, and both groups received Zhibitai （480 mg/d） and Simvastatin （20 mg/d） for 12 momhs, respectively. The blood lipid, creatine .kinase, liver and renal function, and the carotid plaques before and after the treatment were determined by biochemical analyzer and Doppler ultrasonography, respectively. [Results] TC, TG and LDL-C levels decreased （P〈0.05）, and HDL-C contents increased significantly （P 〈0.05） after Zhibitai or Simvastatin treatment. The atheromatons plaques of carotidartery in both groups showed obvious resolution, the difference between two groups was not statistically significant （P〉0.05）. [Conclusion] The lipid-lowering efficacy and carotid plaque resolution of Zhibitai are similar to those of simvastain in patients with hyperlipemia.

关 键 词：脂必泰 辛伐他汀 颈动脉斑块 安全性 

分 类 号：R543.5[医药卫生—心血管疾病]