双水平气道内正压通气在急性左心衰竭患者初始治疗中的应用  

Application of bi-level positive airway pressure ventilation in initial treatment of acute left ventricular failure

作　　者：张奕威 张哲 陈咏佳 巫丽萍 刘光晃 

机构地区：[1]广东省阳江市人民医院,广东阳江529500

出　　处：《广东医学院学报》2012年第6期614-616,共3页Journal of Guangdong Medical College

摘　　要：目的观察双水平气道内正压通气(BiPAP)在急性左心衰竭(ALVF)初始治疗中的临床疗效。方法 78例ALVF患者随机分为观察组和对照组,两组采用相同的常规药物治疗,观察组加用BiPAP。观察两组患者治疗前及治疗后1h临床症状、血气分析和24h血浆脑利钠肽(BNP)水平变化。结果治疗后1h,观察组PaO2与PO2/FiO2较对照组高,而呼吸频率减少(P<0.05)。治疗后24h,两组患者血浆BNP水平均较治疗前下降(P<0.05),但观察组下降更显著(P<0.05)。结论 ALVF患者在初始治疗中使用BiPAP,可迅速改善临床症状和低氧血症,降低血浆BNP水平。Objective To observe the clinical effect of bi-level positive airway pressure ventilation （BiPAP） on the initial treatment of acute left ventricular failure （ALVF）. Methods Seventy-eight ALVF patients were divided into observation group （n=39） and control group （n=39）. Both groups received the same conventional drug therapy, but BiPAP was added in observation group. Clinical symptoms and blood gas analysis were recorded at 1 h, and plasma brain natriuretic peptide （BNP） level was detected at 24 h after treatment in both groups. Results Compared with control group, PaO2与 PO2/FiO2 increased but respiratory rate decreased at 1 h in observation group （P〈0.05）. BNP level decreased at 24 h in both groups, especially in observation group （P〈0.05）. Conclusion BiPAP can rapidly improve the clinical symptoms and hypoxemia and reduce plasma BN-P level in the initial treatment of ALVF patients.

关 键 词：正压通气 急性左心衰竭 脑利钠肽 

分 类 号：R541.6[医药卫生—心血管疾病]