D-二聚体定量检测对判定不稳定性心绞痛血栓成分的临床意义  

The clinical significance of test D-dimer in judging the composition of unstable angina coronary thrombi

作　　者：孟涛[1] 张晋兰[1] 周春兰[2] 马文英[1] 蔡芙莉[1] 贾莉慧 胡凯[2] 王健[2] 闫峻 

机构地区：[1]西安市中心医院心内科,陕西西安710003 [2]西安市中心医院血液病研究所,陕西西安710003

出　　处：《心脏杂志》2000年第4期267-269,共3页Chinese Heart Journal

摘　　要：目的 :探讨 D-二聚体检测在判定不稳定性心绞痛 (UAP)血栓成分的价值及临床意义。方法 :选择住院按亚型诊断、分组的 UAP患者 5 6例 ,急性心肌梗死 (AMI)患者 16例 ,稳定性心绞痛 (SAP)患者 2 3例 ,采用胶体金方法动态检测患者静脉血中的 D-二聚体含量。结果 :UAP亚组中 D-二聚体含量 :初发型 0 .73± 0 .31mg/ L ;恶化型 1.0 8± 0 .36 mg/ L ;混合型 0 .49± 0 .10 mg/ L ;梗死后 0 .76± 0 .2 1mg/ L ;AMI组 1.83± 0 .6 4m g/ L。与 SAP组 D-二聚体含量 0 .38± 0 .16 m g/ L比较 ,均存在显著差异 (P<0 .0 5 )。恶化组、AMI组与 SAP组比较 ,差异最为显著 (P<0 .0 1)。结论 :D-二聚体定量检测是判定 U AP血栓形成、血栓成分相对特异的敏感指标。Aim:To study the value and clinical significance of D dimer in judging the composition coronary artery thrombi of unstable angina(UAP) patients. Methods:Fifty six hospitalized patients group diagnosed and categorized as UAP,16 paitents as acute myocardial infarction (AMI), 23 patients as stable angina pectoris(SAP). The D dimer in their venous blood were ested dymatically by ELISA methods. Results:D dimer in UAP group:new angina 0.73±0.31 mg/L; accelerated angina 1.08±0.36 mg/L;mixed angina 0.49±0.10 mg/L;postinfarction unstable angina 0.76±0.21 mg/L;AMI group 1.83±0.64 mg/L. The content of D dimer in SAP 0.38±0.16 mg/L. The difference is significant(P<0.05). The accelerated angina group and AMI group compared with SAP group seperately,the difference is more sigificant(P<0.01). Conclusion:Test the content of D dimer is a comparative distinctive sensitive marker in the judgement of coronary thrombosis and its composition.

关 键 词：D-二聚体 心绞痛 心肌梗死 血栓 病理 

分 类 号：R541.402[医药卫生—心血管疾病]