慢性自发性荨麻疹患者血清IL-17、IL-23水平的检测及意义  

Serum Levels of IL-17,IL-23 in Patients with Chronic Spontaneous Urticaria

作　　者：李润祥[1] 梁碧华[1] 杨婧[1] 熊斯颖[1] 马少吟[1] 梁艳华[1] 朱慧兰[1] 

机构地区：[1]广州市皮肤病防治所,广东广州510095

出　　处：《皮肤性病诊疗学杂志》2013年第1期19-21,共3页Journal of Diagnosis and Therapy on Dermato-venereology

基　　金：广东省自然科学基金项目(编号:S2012020011077);广州市科技计划项目(编号:2009Z1-E011);广州市卫生局医药卫生科技项目(编号:201102A213196)

摘　　要：目的:探讨白细胞介素-17(Interlenkin-17,IL-17)、白细胞介素-23(Interleukin-23,IL-23)在慢性自发性荨麻疹患者中的表达及意义。方法:选取慢性自发性荨麻疹患者和健康献血者各30例,用酶联免疫吸附法检测血清中IL-17、IL-23水平,并分析它们与病情、病程之间的关系。结果:慢性自发性荨麻疹患者的血清IL-17水平[(19.3±8.1)pg/mL]、IL-23水平[(28.9±11.1)pg/mL]均高于对照组[(8.6±5.7)pg/mL,(10.9±6.2)pg/mL],组间比较差异有统计学意义(t值分别为5.92、7.72,P值均<0.01)。慢性自发性荨麻疹患者IL-17、IL-23与症状评分呈正相关关系(r=0.89、r=0.75,P值均<0.01),与病程无明显相关性(r=0.23、r=0.24,P值均>0.05),IL-17与IL-23呈正相关关系(r=0.81,P<0.01)。结论:IL-17、IL-23在慢性自发性荨麻疹发病机理中可能起着重要作用。Objective：To study the serum levels of IL-17 and IL-23 in the patients with chronic spontaneous urticaria. Methods： 30 patients with chronic spontaneous urticaria as a CSU group and 30 healthy people as the control group were assigned. The serum levels of IL-17 and IL-23 were determined by ELISA. Results： Serum levels of IL-17 and IL-23 in CSU group （ 19.3 ± 8. 1 pg/mL, 28.9±11.1 pg/mL） were significantly higher than those in control group （ 8.6 ± 5.7 pg/mL,10. 9 ±6.2 pg/mL（t =5.92, 7.72, respectively, P 〈0.01 ）. Serum levels of IL-17 and IL-23 were positively correlated to the score of the patients with CSU （r = 0. 89 ,r = 0. 75 respec- tively,P 〈0. 01 ）, but not correlated to the course of disease（r =0. 23,r =0. 24 respectively,P 〉 0. 05 ）. Serum level of IL-17 was positively correlated to that of IL-23 significantly （r = 0. 81 ,P 〈 0. 01 ）. Conclusion：IL-17 and IL-23 may participate in the pathogenesis of chronic spontaneous urticaria.

关 键 词：慢性自发性荨麻疹 白细胞介素-17 白细胞介素-23 发病机制 

分 类 号：R758.24[医药卫生—皮肤病学与性病学]